Results 131 to 140 of about 23,081,151 (331)

Uncertainty in GRACE/GRACE-follow on global ocean mass change estimates due to mis-modeled glacial isostatic adjustment and geocenter motion. [PDF]

Sci Rep, 2022
Kim JS, Seo KW, Chen J, Wilson C.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Author Correction: Split westerlies over Europe in the early Little Ice Age

Nature Communications, 2023
Hsun-Ming Hu, Chuan-Chou Shen, John C. H. Chiang, Valerie Trouet, Véronique Michel, Hsien-Chen Tsai, Patricia Valensi, Christoph Spötl, Elisabetta Starnini, Marta Zunino, Wei-Yi Chien, Wen-Hui Sung, Yu-Tang Chien, Ping Chang, Robert Korty   +14 more
doaj   +1 more source

How much does fat mass change affect serum uric acid levels among apparently clinically healthy Korean men? [PDF]

Ther Adv Musculoskelet Dis, 2021
Ahn JK, Hwang J, Lee MY, Kang M, Hwang J, Koh EM, Cha HS.   +6 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Study on Annual Signals of Greenland Ice Sheet Mass and Associated Influencing Factors Based on GRACE/GRACE-FO Data

Land
As global temperatures rise, the Greenland ice sheet (GrIS) is undergoing accelerating mass loss, with significant implications for sea level rise and climate systems.
Kaifeng Ma, Jing Han, Zhen Li, Junzhen Meng, Qingfeng Hu, Peipei He, Changxu Yao   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Present‐Day Three‐Dimensional Crustal Deformation Velocity of the Tibetan Plateau Due to Multi‐Component Land Water Loading

Geophysical Research Letters
Quantitative understanding of the land water loading is a prerequisite to the construction of reliable tectonic deformation velocity field in the Tibetan Plateau (TP).
Jiashuang Jiao, Yuanjin Pan, Ding Ren, Xiaohong Zhang   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source