Results 51 to 60 of about 79,273 (290)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Social Housing Customization in Brazil

open access: yesEncyclopedia, 2021
Social housing customization in Brazil refers to the current processes of development and evolution of government-funded neighborhoods for the lowest-income population.
Luisa Felix Dalla Vecchia   +1 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Study on the Structured Processing of Unstructured Personalized Customer Requirement for Mass Customization

open access: yesDianxin kexue, 2013
Mass customization is a new model of manufacturing and services. Customers' personalized service requirement in mass customization often have the unstructured characteristics, and obtaining and analyzing customers' real requirements accurately is the key
Qinglie Wu, Yu Guo
doaj   +2 more sources

Why Customers Value Mass-customized Products: The Importance of Process Effort and Enjoyment [PDF]

open access: yes, 1998
We test our hypotheses on 186 participants designing their own scarves with an MC toolkit. After completing the process, they submitted binding bids for "their" products in Vickrey auctions.
David, G.   +5 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Customers’ online shopping preferences in mass customization [PDF]

open access: yesJournal of Direct, Data and Digital Marketing Practice, 2013
Mass customization has become important to business because of the difficulties for customers in finding what they want despite an increase in product variety for many categories over the past decades. The emergence of modern technologies in production and communication, however, allows companies to offer customised products and services without ...
AICHNER, THOMAS, P. Coletti
openaire   +2 more sources

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone   +8 more
wiley   +1 more source

Consumer Preferences for Mass Customization [PDF]

open access: yes, 2004
Increasingly, firms adopt mass customization, which allows consumers to customize products by self-selecting their most preferred composition of the product for a predefined set of modules.
Dellaert, B.G.C. (Benedict)   +1 more
core  

Selecting a Customization Strategy Under Competition: Mass Customization, Targeted Mass Customization, and Product Proliferation [PDF]

open access: yesIEEE Transactions on Engineering Management, 2007
Customization requires not only an implementation of proper manufacturing systems but also a proper strategy regarding when firms should offer customized products and what the nature of customization should be. This paper questions 1)whether customization is better than no customization, and, if so, 2) what kind of customization strategy firms should ...
Hasan Cavusoglu   +2 more
openaire   +1 more source

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