Results 111 to 120 of about 983,966 (332)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]

, 2013
In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB, Boyle, SH, Churchill, E, Delnomdedieu, M, Fiehn, O, Kaddurah-Daouk, R, Krishnan, RR, Pickering, E, Rush, AJ, Wang, Z, Wikoff, WR, Zhu, H   +11 more
core   +2 more sources

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

NMR-based pharmacometabonomics: A new paradigm for personalised or precision medicine [PDF]

, 2017
Metabolic profiling by NMR spectroscopy or hyphenated mass spectrometry, known as metabonomics or metabolomics, is an important tool for systems-based approaches in biology and medicine.
Abo, Allalou, Anderssen, Andersson, Ashline, Backshall, Baker, Beckett, Beckonert, Bharti, Bingol, Bingol, Bouatra, Bylesjo, Chen, Clayton, Clayton, Coen, Condray, Craig, Creek, Cunningham, Dai, Daly, Ellero-Simatos, Emwas, Everett, Everett, Everett, Everett, Everett, Fennema, Fiehn, Fiehn, Gamage, Golland, Gupta, Halket, Hao, Huang, Jain, Jeremy R. Everett, Ji, Joseph, Kaddurah-Daouk, Kaddurah-Daouk, Kaddurah-Daouk, Kapoor, Karas-Kuzelicki, Keun, Kim, Kwon, Larive, Lazarou, Lewis, Lewis, Li, Lindon, Lindon, Lindon, Lindon, Liu, Marshall, Maruthur, Miolo, Muhrez, Nam, Navarro, Nicholson, Nicholson, Oliver, Perlis, Phapale, Pirmohamed, Puskarich, Rahmioglu, Robinette, Rotroff, Rubingh, Salari, Sanchon-Lopez, Schymanski, Shah, Shin, Shin, Sumner, Szymanska, Trupp, Trygg, Ulrich, Varshavi, Veselkov, Wang, Wang-Sattler, Want, Weng, Winnike, Wishart, Yerges-Armstrong, Zhang, Zhu   +100 more
core   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Spatial clustering of filarial transmission before and after a Mass Drug Administration in a setting of low infection prevalence. [PDF]

, 2004
Charles Washington, Jeanne Radday, Thomas G. Streit, Heather A. Boyd, Michael J. Beach, David G. Addiss, Rodrigue Lovince, Maribeth C. Lovegrove, Jack Guy Lafontant, Patrick J. Lammie, Allen W. Hightower   +10 more
openalex   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Mass drug administration: time to consider drug pollution? [PDF]

The Lancet, 2020
Unax Lertxundi, Gorka Orive
openaire   +3 more sources

Mass drug administration and the sustainable control of schistosomiasis: Community health workers are vital for global elimination efforts

International Journal of Infectious Diseases, 2018
Objectives: Schistosomiasis control is centred on preventive chemotherapy through mass drug administration (MDA). However, endemic countries continue to struggle to attain target coverage rates and patient compliance.
Marianette T. Inobaya, Thao N. Chau, Shu-Kay Ng, Colin MacDougall, Remigio M. Olveda, Veronica L. Tallo, Jhoys M. Landicho, Carol M. Malacad, Mila F. Aligato, Jerric R. Guevarra, Allen G. Ross   +10 more
doaj   +1 more source