Results 121 to 130 of about 1,239,019 (334)

Mectizan® procurement and delivery for onchocerciasis mass drug administration programmes

Acta Tropica, 2011
The discovery of Mectizan has engendered a safe onchocerciasis chemoprevention tool. To make the drug available promptly to people at risk of onchocerciasis, a procurement and delivery mechanism has been put in place around the Mectizan Donation Program, which oversees the Merck donation of Mectizan.
Ogoussan, Kisito T., Hopkins, Adrian
openaire   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Does mass drug administration of azithromycin reduce child mortality?

The Lancet Global Health, 2021
Samwel Maina Gatimu, Rachel Wangari Kimani   +1 more
doaj   +1 more source

Mass drug administration: time to consider drug pollution? [PDF]

The Lancet, 2020
Gorka, Orive, Unax, Lertxundi
openaire   +2 more sources

Mass Drug Administration for Scabies — 2 Years of Follow-up

New England Journal of Medicine, 2019
Ivermectin for Scabies In this 2-year follow-up report in Fiji, the single mass administration of oral ivermectin was more effective in reducing the prevalence of both scabies and impetigo than eit...
Romani, L, Whitfeld, MJ, Koroivueta, J, Kama, M, Wand, H, Tikoduadua, L, Tuicakau, M, Koroi, A, Andrews, RM, Kaldor, JM, Steer, AC   +10 more
openaire   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Elimination of lymphatic filariasis: current perspectives on mass drug administration

Research and Reports in Tropical Medicine, 2018
John O Gyapong,1 Irene O Owusu,2 Frances B da-Costa Vroom,3 Ernest O Mensah,4 Margaret Gyapong5 1Centre for Neglected Tropical Diseases Research, Institute of Health Research, University of Health and Allied Sciences, Ho, 2Department of Epidemiology ...
Gyapong JO, Owusu IO, da-Costa Vroom FB, Mensah EO, Gyapong M   +4 more
doaj  

Mass drug administration and the sustainable control of schistosomiasis: Community health workers are vital for global elimination efforts

International Journal of Infectious Diseases, 2018
Objectives: Schistosomiasis control is centred on preventive chemotherapy through mass drug administration (MDA). However, endemic countries continue to struggle to attain target coverage rates and patient compliance.
Marianette T. Inobaya, Thao N. Chau, Shu-Kay Ng, Colin MacDougall, Remigio M. Olveda, Veronica L. Tallo, Jhoys M. Landicho, Carol M. Malacad, Mila F. Aligato, Jerric R. Guevarra, Allen G. Ross   +10 more
doaj   +1 more source

POST MASS DRUG ADMINISTRATION ASSESSMENT OF COVERAGE, COMPLIANCE, AND OBSTACLES IN A LYMPHATIC FILARIASIS ENDEMIC DISTRICT OF CENTRAL INDIA.

, 2023
Neelam Anupama Toppo, Aditya Thakur, Deepali Soni, Tej Pratap Singh   +3 more
openalex   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source