Results 211 to 220 of about 26,667,629 (348)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale
The Astrophysical Journal LettersWithin the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Association of Diet Quality with Low Muscle Mass-Function in Korean Elderly. [PDF]
Int J Environ Res Public Health, 2019 Jung M, Park S, Kim H, Kwon O.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2005 A non-parametric statistical model is constructed to directly relate The distribution of observed microlens timescales to that of the mass Function of the population from which the lenses are drawn, corrected For observational selection based on timescales and event amplifications.
openaire +2 more sources
, 1894 V. 1 printed under the direction of Benj. P. Mighill and Geo. B. Blodgette, a committee of the town.Cover-title.v. 1. The early records of the town ...
Rowley, Mass.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Cosmological Mass Function
, 1997 PhD thesis, in press on Fund. Cosm. Phys.; 94 pages, figures included, fig.
openaire +3 more sources