Results 71 to 80 of about 667,105 (293)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Economics of Cell Partitions And Closures Produced by \u3ci\u3ePassaloecus Cuspidatus (Hymenoptera: Sphecidae) [PDF]

, 2017
Sphecid wasps, Passaloecus cuspidatus were observed gathering fresh pine resin (Pinus strobus) which they used for creating partitions and closures in their nests.
Fricke, John M
core   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Mass and Mission: Enacting God\u27s Mission in the Christian Assembly Today [PDF]

, 2006
(Excerpt) I doubt that I need to underscore the ferment surrounding the matters that are the theme of this year\u27s Institute: worship and mission. The practice of worship in our congregations has become fragmented by multiple and competing proposals ...
Schattauer, Thomas H
core   +1 more source

Gathering preliminary data [PDF]

, 2017
Prior to any large-scale basic science or clinical research project being funded, it is important for researchers to gather preliminary data. This is essential for providing evidence for the feasibility of research projects and helping to design larger ...
Kasivisvanathan, Veeru, Salji, Mark J., Winchester, Catherine L.   +2 more
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Influenza Outbreaks during World Youth Day 2008 Mass Gathering

Emerging Infectious Diseases, 2010
Influenza outbreaks during mass gatherings have been rarely described, and detailed virologic assessment is lacking. An influenza outbreak occurred during World Youth Day in Sydney, Australia, July 2008 (WYD2008).
Christopher C. Blyth, Hong Foo, Sebastiaan J. van Hal, Aeron C. Hurt, Ian G. Barr, Kenneth McPhie, Paul K. Armstrong, William D. Rawlinson, Vicky Sheppeard, Stephen Conaty, Michael Staff, Dominic E. Dwyer   +11 more
doaj   +1 more source

Particle creation in gravitational collapse to a horizonless compact object

, 2018
Black holes (BHs) play a central role in physics. However, gathering observational evidence for their existence is a notoriously difficult task. Current strategies to quantify the evidence for BHs all boil down to looking for signs of highly compact ...
Cardoso, Vitor, Harada, Tomohiro, Miyata, Daiki   +2 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source