Results 41 to 50 of about 580 (166)

Factors Affecting the Communicating Risk During Public Health Emergencies

Saudi Journal of Emergency Medicine
Background: Risk communication during public health emergencies is a demanding and dynamic public policy process. In this paper, we provide an overview of risk communication during public health emergencies by discussing the theoretical foundations of ...
Yasir Almuzaini, Mariyyah Alburayh, Ahmed Alahmri, Fahad Alamri, Haytham Sheerah, Anas Khan   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Critical determinants of morbidity and adverse outcomes during the Hajj using the Haddon matrix and the combined model

Scientific Reports
Hajj, the annual pilgrimage to Makkah, Saudi Arabia, attracts around two million Muslims from across the globe, making it one of the world’s largest mass gatherings.
Yasir Almuzaini, Fahad Alamri, Lamis Alabdullatif, Anas Khan   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Hajj: Health lessons for mass gatherings

Journal of Infection and Public Health, 2008
The potential for spread of infectious diseases associated with mass gatherings is well recognised. Hajj, the unique annual mass gathering of over 2 million Muslims from all over the world, presents enormous challenges to the authorities in Saudi Arabia.
Shuja Shafi, Robert Booy, Elizabeth Haworth, Harunor Rashid, Ziad A. Memish   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Implementing Telemedicine Intervention in Neonatal Intensive Care Units: Augmented Teleconsultation and Real-Time Monitoring Experience

Telemedicine Reports
Background: Increasing intensivist shortages and demand, coupled with the escalating bed occupancy rate due to increased demand for neonatal intensive care units (NICUs), have created enthusiasm for tele-critical care (TCC) in the form of ...
Dalia M. Mominkhan, Faisal Aldahmashi, Ali H. Almudeer, Abdulaziz S. Alhmod, Muaddi F. Alharbi, Lamya M. Alzubaidi, Nada K. Alwehaibi, Khalid N. Alobeiwi, Manea M. Balharith, Ahmed A. Alahmari, Fahad A. Alamri, Ghadah Alsaleh, Yaser Almuzaini, Mohammed K. Alabdulaali   +13 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Preparation for mass gathering events from the perspective of a non-host country: the experience of Japan during the 2018 PyeongChang Olympics and Paralympic Winter Games

Western Pacific Surveillance and Response, 2019
The World Health Organization recommends that countries or organizations that host mass gatherings plan ahead and prepare for possible public health events to ensure a safe environment for local residents, participants and travellers.1 Public health ...
Kazuaki Jindai, Takuya Yamagishi, Munehisa Fukusumi, Shingo Nishiki, Yusuke Kobayashi, Yusuke Matsui, Tamano Matsui, Kazunori Oishi   +7 more
doaj   +1 more source