Results 51 to 60 of about 4,973,131 (354)
To the problem of development of low-rise housing in Russia [PDF]
E3S Web of Conferences, 2019 The issue of providing the population with comfortable and affordable housing has always been rather acute in our country. The solution to this problem, taking into account the trends in the creation and transformation of the urban environment into the ...
Tusnina Valentina, Yakovleva Ekaterina
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
An Examination of Mass Housing Residents' Satisfaction with Social Sustainability
International Journal of Built Environment and Sustainability, 2023 With an increased demand for housing, mass housing focuses on speed and economic benefit and standardizes. Different user groups cannot find answers to some of their physical and social needs in this housing and its ...
Kübra Bıyuk Öksüz +1 more
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‘Sun, air, and homes for all’? Soviet variations on european experiences of mass housing construction during the first five-year plans [PDF]
, 2016 The article was submitted on 15.05.2016.Статья посвящена малоизученному аспекту советского градостроительства – трансформации зарубежного опыта жилищного строительства в годы первых пятилеток.
Konysheva, E., Конышева, Е.
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Code for sustainable homes: opportunities or threats for offsite manufacturing and mass-customization? [PDF]
, 2013 This study intends to, firstly, discuss current status of zero carbon homes in the UK, and secondly, to investigate the feasibility of using offsite construction methods to deliver mass customised zero carbon homes.
Hadjri, Karim, Hashemi, Arman
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Place after prison: neighborhood attachment and attainment during reentry [PDF]
, 2018 Over 600,000 people leave prison and become residents of neighborhoods across the United States annually. Using a longitudinal survey of people returning to Greater Boston, this study examines disparities in neighborhood attainment after prison ...
Simes, Jessica T.
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source