Results 111 to 120 of about 1,918,733 (356)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Mass loss on the asymptotic giant branch

open access: yes, 2006
Mass loss on the Asymptotic Giant Branch provides the origin of planetary nebulae. This paper reviews several relevant aspects of AGB evolution: pulsation properties, mass loss formalisms and time variable mass loss, evidence for asymmetries on the AGB ...
Zijlstra, Albert A.; id_orcid
core   +1 more source

Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica [PDF]

open access: hybrid, 2020
Chris Turney   +31 more
openalex   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

The effect of mass loss in models of red supergiants in the Small Magellanic Cloud

open access: yes
The rate and mechanism of mass loss of red supergiants (RSGs) remain poorly understood. Motivated by a new empirical mass-loss rate prescription based on the largest and most complete sample of RSGs in the Small Magellanic Cloud (SMC), we investigate the
Gossage, Seth   +47 more
core   +1 more source

Glacial lakes exacerbate Himalayan glacier mass loss [PDF]

open access: yes, 2019
This study was supported by the Swiss National Science Foundation (Grant No. IZLCZ2_169979/1) the Dragon 4 project funded by ESA (4000121469/17/I-NB) and the Strategic Priority Research Program of Chinese Academy of Sciences (XDA20100300).Heterogeneous ...
Bhambri, Rakesh   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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