Results 131 to 140 of about 1,918,733 (356)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Modelling of heat and mass transfer processes in neonatology

, 2008
This paper reviews some of our recent applications of Computational Fluid Dynamics (CFD) to model heat and mass transfer problems in neonatology and investigates the major heat and mass transfer mechanisms taking place in medical devices such as ...
Ginalski, MK, Wrobel, LC, Nowak, AJ
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Continuous stellar mass-loss in

, 2001
We present an N-body computer code -aimed at studies of galactic dynamics - with a CPU-efficient algorithm for a continuous (i.e. time-dependent) stellar mass-loss. First, we summarize available data on stellar mass-loss and derive the long-term (20 Gyr)
F. Combes, B. Jungwiert, J. Palouš
core   +1 more source

Irreversible mass loss of Canadian Arctic Archipelago glaciers [PDF]

, 2013
Jan T. M. Lenaerts, J. H. van Angelen, M. R. van den Broeke, Alex Gardner, Bert Wouters, Erik van Meijgaard   +5 more
openalex   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A distributional approach to fragmentation equations

, 2011
We consider a linear integro-di®erential equation that models multiple fragmentation with inherent mass-loss. A systematic procedure is presented for constructing a space of generalised functions Z0 in which initial-value problems involving singular ...
Lamb, Wilson, Mcbride, Adam
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Recessions and the Cost of Job Loss [PDF]

We develop new evidence on the cumulative earnings losses associated with job displacement, drawing on longitudinal Social Security records for U.S. workers from 1974 to 2008.
Steven J. Davis, Till M. von Wachter
core  

Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer?

, 2014
BackgroundIGF-1 plays a role in the growth of multiple tumor types, including pancreatic cancer. IGF-1 also serves as a growth factor for muscle. The impact of therapeutic targeting of IGF-1 on muscle mass is unknown.MethodsWe evaluated muscle mass at L3
Katz, M. H., Overman, M. J., Lieffers, J., Shroff, R., Fogelman, D., Varadhachary, G. R., Javle, M., Khalil, M., Prado, C. M., Holmes, H.   +9 more
core   +1 more source