Results 91 to 100 of about 11,395,261 (251)

Preliminary estimates of mass-loss rates, changes in stable isotope composition, and invertebrate colonisation of evergreen and deciduous leaves in a Waikato, New Zealand, stream. [PDF]

, 1999
Rates of mass loss are important in the choice of tree species used in riparian rehabilitation because leaves that break down fast should contribute to stream food-webs more rapidly than leaves that break down more slowly.
Laboyrie, J. Lee, Hicks, Brendan J., Brendan J. Hicks, J. Lee Laboyrie   +3 more
core   +1 more source

StarStream on Gaia: Stream Discovery and Mass-loss Rate of Globular Clusters

The Astrophysical Journal Supplement Series
We apply the automatic stellar stream detection algorithm StarStream to Gaia Data Release 3 and identify 87 stellar streams associated with Galactic globular clusters (GCs), including 34 high-quality cases with median completeness and purity both ...
Yingtian Chen, Oleg Y. Gnedin, Adrian M. Price-Whelan   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Combustion Evolution of Aviation Kerosene Pools in Confined Spaces Under Mechanical Negative Pressure

Fire
This study experimentally investigates the combustion behavior of RP-3 aviation kerosene pool fires (300~800 mm) within a confined space, specifically focusing on the complex interaction between buoyancy-driven plumes and mechanical negative pressure ...
Haoshi Sun, Jing Luo, Pincong Wu, Jizhe Wang, Yuxian Bing, Mengqi Yuan, Xijing Li, Yuanzhi Li, Xinming Qian, Qi Zhang   +9 more
doaj   +1 more source

Regional differences in global glacier retreat from 1980 to 2015

Advances in Climate Change Research, 2019
Global warming triggers shrinking and thinning of glaciers worldwide, with potentially severe implications for human society. However, regional differences in glacier retreat and its relationship with climatic characteristics have not been conclusively ...
Yao-Jun Li, Yong-Jian Ding, Dong-Hui Shangguan, Rong-Jun Wang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Improved Prediction of Freeze–Thaw Resistance of Steel-Fiber-Reinforced Concrete in Cold-Region Tunnels Based on Machine Learning

Buildings
The durability and serviceability of steel-fiber-reinforced concrete (SFRC) tunnel linings in cold regions are significantly challenged by repeated freeze–thaw actions, making the accurate prediction of frost resistance a critical engineering problem ...
Yi Yang, Tan-Tan Zhu, Xin Zhao, Hua Luo, Bo-Yang Liu, Tong-Tong Kong, Jun Tao, Fei Zhang   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source