Results 111 to 120 of about 1,250,119 (305)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A distributional approach to fragmentation equations
, 2011 We consider a linear integro-di®erential equation that models multiple fragmentation with inherent mass-loss. A systematic procedure is presented for constructing a space of generalised functions Z0 in which initial-value problems involving singular ...
Lamb, Wilson, Mcbride, Adam
core
Study on Freeze–Thaw Resistance of Cement Concrete with Manufactured Sand Based on BP Neural Network
BuildingsIn this study, experiments were conducted on the freeze–thaw performance of manufactured sand cement concrete with different sand ratios and fly ash contents.
Hengyu Wu, Qiju Gao
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Silva FennicaIn boreal forests fires often ignite and spread within the dominant moss and lichen cover of the ground layer vegetation, which thus greatly influences fire hazard.
Henrik Lindberg +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Modelling of heat and mass transfer processes in neonatology
, 2008 This paper reviews some of our recent applications of Computational Fluid Dynamics (CFD) to model heat and mass transfer problems in neonatology and investigates the major heat and mass transfer mechanisms taking place in medical devices such as ...
Ginalski, MK, Wrobel, LC, Nowak, AJ
core
Regional differences in global glacier retreat from 1980 to 2015
Advances in Climate Change Research, 2019 Global warming triggers shrinking and thinning of glaciers worldwide, with potentially severe implications for human society. However, regional differences in glacier retreat and its relationship with climatic characteristics have not been conclusively ...
Yao-Jun Li +3 more
doaj +1 more source