Results 121 to 130 of about 1,250,119 (305)

New theoretical Mass-loss rates of O and B Stars

Astronomy & Astrophysics, 2000
Accepted by A&A, 16 pages Latex, 11 ...
Vink, J.S., de Koter, A., Lamers, H.J.G.L.M.   +2 more
openaire   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Sirius A: turbulence or mass loss?

, 2011
Context. Abundance anomalies observed in a fraction of A and B stars of both Pop I and II are apparently related to internal particle transport. Aims.
M. Vick, G. Michaud, Michaud, G., Richer, J., Vick, M., J. Richer   +5 more
core   +1 more source

Combustion Evolution of Aviation Kerosene Pools in Confined Spaces Under Mechanical Negative Pressure

Fire
This study experimentally investigates the combustion behavior of RP-3 aviation kerosene pool fires (300~800 mm) within a confined space, specifically focusing on the complex interaction between buoyancy-driven plumes and mechanical negative pressure ...
Haoshi Sun, Jing Luo, Pincong Wu, Jizhe Wang, Yuxian Bing, Mengqi Yuan, Xijing Li, Yuanzhi Li, Xinming Qian, Qi Zhang   +9 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Improved Prediction of Freeze–Thaw Resistance of Steel-Fiber-Reinforced Concrete in Cold-Region Tunnels Based on Machine Learning

Buildings
The durability and serviceability of steel-fiber-reinforced concrete (SFRC) tunnel linings in cold regions are significantly challenged by repeated freeze–thaw actions, making the accurate prediction of frost resistance a critical engineering problem ...
Yi Yang, Tan-Tan Zhu, Xin Zhao, Hua Luo, Bo-Yang Liu, Tong-Tong Kong, Jun Tao, Fei Zhang   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimal prediction under asymmetric loss [PDF]

Prediction problems involving asymmetric loss functions arise routinely in many fields, yet the theory of optimal prediction under asymmetric loss is not well developed.
Francis X. Diebold, Peter F. Christoffersen   +1 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source