Results 21 to 30 of about 5,059 (166)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An Investigation on the Migration and Settlement Law of Temporary Plugging Particles in Horizontal Wellbore

Geofluids, 2021
Migration and settlement of temporary plugging particles of different sizes affect the effect of temporary plugging, which in turn affect the effect of reservoir reconstruction.
Yao Luo, Hao Lang, Dan Yang, Xianli Wen, Jianshe Guo, Hui Kong, Xue Meng, Shaobo Han, Fujian Zhou   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Socio-economic consequences for Central Europe related to the mass migration of Ukrainian citizens after Russia's full-scale invasion [PDF]

Revista UNISCI
The Russian invasion of Ukraine has caused displacement on a scale not seen since the Second World War. More than 6.5 million refugees from Ukraine have been registered worldwide (as of 16 May 2024), and more than 4.2 million Ukrainians have received ...
Łukasz Jureńczyk , Svitlana Soroka
doaj  

Influence of pulsating hydraulic parameters on migration law of deposited particles in fracture

Meikuang Anquan, 2022
In order to improve the dredging effect of the blocked mining-induced fracture field by pulsating hydraulic scouring technology, the flow characteristics of pulsating water flow in fracture and the influence of pulsating hydraulic parameters on the ...
LIU Yingke, WEN Xiaojiang, CHEN Shuaiyu, YE Guoqing   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Governance And Mass Migration Of Nigerians Abroad: The Causes And Consequences

Journal of Governance and Administrative Reform
The optimism that civilian administration in Nigeria's Fourth Republic would catalyze unparalleled development has gradually waned as Nigerians continue to grapple with precarious economic conditions.
Adeleke Adegbami, Biola Muhibat Osungboye   +1 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source