Results 151 to 160 of about 1,066,264 (303)

Mussel mass mortality in the Clinch River, USA: metabolomics detects affected pathways and biomarkers of stress. [PDF]

Conserv Physiol, 2023
Putnam JG, Steiner JN, Richard JC, Leis E, Goldberg TL, Dunn CD, Agbalog R, Knowles S, Waller DL.   +8 more
europepmc   +1 more source

Demographic, Residential, and Socioeconomic Effects on the Distribution of 19th Century African-American Body Mass Index Values [PDF]

Little research exists on the body mass index values of late 19th and early 20th century African-Americans. Using a new BMI data set and robust statistics, this paper demonstrates that late 19th and early 20th century black BMI variation by age increased
Scott A. Carson
core  

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Mass mortality of the keratose sponge Sarcotragus foetidus in the Aegean Sea (Eastern Mediterranean) correlates with proliferation of Vibrio bacteria in the tissues. [PDF]

Front Microbiol, 2023
Dinçtürk E, Öndes F, Leria L, Maldonado M.   +3 more
europepmc   +1 more source

Infant mortality by maternal prepregnancy body mass index : United States, 2017\u20132018 [PDF]

Objective\u2014This report presents 2017\u20132018 infant mortality rates in the United States by maternal prepregnancy body mass index, and by infant age at death, maternal age, and maternal race and Hispanic origin.Methods\u2014Descriptive tabulations ...

core  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Gut microbiota of the critically endangered Saiga antelope across two wild populations in a year without mass mortality. [PDF]

Sci Rep, 2023
Hanski E, Khanyari M, Li J, Bates KA, Zuther S, Maiden MCJ, Kock R, Knowles SCL.   +7 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Rapid Evolution in a Coral Population Following a Mass Mortality Event. [PDF]

Evol Appl
Fifer JE, Speare KE, Leinbach SE, Hendricks SF, Davies SW, Rose NH, Burkepile DE, Adam TC, Hofmann GE, Strader ME.   +9 more
europepmc   +1 more source