Results 171 to 180 of about 1,066,264 (303)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Correction: Erysipelothrix rhusiopathiae clone reemergence in association with a multi-year mass mortality event in high Arctic muskoxen (Ovibos moschatus). [PDF]

Sci Rep
Wooten MT, Forde TL, Roberto-Charron A, Fredlund M, Mullin T, Christensen OA, Schneider A, Radhakrishnan S, Goldsmith D, Morrison B, Lau E, Mavrot F, Seru LV, Fang T, Donovan RM, Cluff HD, van der Meer F, Kutz SJ.   +17 more
europepmc   +1 more source

Mass mortality event in South American sea lions (Otaria flavescens) correlated to highly pathogenic avian influenza (HPAI) H5N1 outbreak in Chile. [PDF]

Vet Q, 2023
Ulloa M, Fernández A, Ariyama N, Colom-Rivero A, Rivera C, Nuñez P, Sanhueza P, Johow M, Araya H, Torres JC, Gomez P, Muñoz G, Agüero B, Alegría R, Medina R, Neira V, Sierra E.   +16 more
europepmc   +1 more source

Mass Animal Mortality Plan, 2019

, 2019
The DNR’s Mass Animal Mortality Plan replaces the FAD plan, giving staff the flexibility to respond to a variety of disease and non‐disease related mass animal mortality events.

core  

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Body-mass index and all-cause mortality [PDF]

The Lancet, 2017
Dominique J, Pepper, Junfeng, Sun, Anthony F, Suffredini, Sameer, Kadri   +3 more
openaire   +4 more sources

Genetic Features of the Scuticociliate Pathogen Philaster sp. Isolate FWC2 That Causes Sea Urchin Mass Mortality. [PDF]

J Eukaryot Microbiol
Lim SJ, Breitbart M.
europepmc   +1 more source

Mass Mortality Caused by Highly Pathogenic Influenza A(H5N1) Virus in Sandwich Terns, the Netherlands, 2022. [PDF]

Emerg Infect Dis, 2022
Rijks JM, Leopold MF, Kühn S, In 't Veld R, Schenk F, Brenninkmeijer A, Lilipaly SJ, Ballmann MZ, Kelder L, de Jong JW, Courtens W, Slaterus R, Kleyheeg E, Vreman S, Kik MJL, Gröne A, Fouchier RAM, Engelsma M, de Jong MCM, Kuiken T, Beerens N.   +20 more
europepmc   +1 more source

150 Years of temperature-related excess mortality in the Netherlands [PDF]

Even in present-day high-income countries, there is a lot of evidence of a high degree of vulnerability of the population to both high and low outdoor temperatures.
Coen van Duin, Peter Ekamper, Joop Garssen, Frans van Poppel   +3 more
core  

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source