Results 51 to 60 of about 1,066,264 (303)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

An Enigmatic Wild Passerine Mortality Event in the Eastern United States

Veterinary Sciences
The ability to rapidly respond to wildlife health events is essential. However, such events are often unpredictable, especially with anthropogenic disturbances and climate-related environmental changes driving unforeseen threats.
Sabrina S. Greening, Julie C. Ellis, Nicole L. Lewis, David B. Needle, Cristina M. Tato, Susan Knowles, Valerie Shearn-Bochsler, Jaimie L. Miller, Daniel A Grear, Jeffrey M. Lorch, David S. Blehert, Caitlin Burrell, Lisa A. Murphy, Erica A. Miller, C. Brandon Ogbunugafor, Andrea J. Ayala, W. Kelley Thomas, Joseph L. Sevigny, Lawrence M. Gordon, Tessa Baillargeon, Lusajo Mwakibete, Megan Kirchgessner, Christine L. Casey, Ethan Barton, Michael J. Yabsley, Eman Anis, Roderick B. Gagne, Patrice Klein, Cindy Driscoll, Chelsea A. Sykes, Robert H. Poppenga, Nicole M. Nemeth   +31 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Uncommon southwest swells trigger sea urchin disease outbreaks in Eastern Atlantic archipelagos

Ecology and Evolution, 2020
Recurrent sea urchin mass mortality has recently affected eastern Atlantic populations of the barren‐forming sea urchin Diadema africanum. This new episode of die‐off affords the opportunity to determine common meteorological and oceanographic conditions
José Carlos Hernández, Carlos Sangil, Jacob Lorenzo‐Morales   +2 more
doaj   +1 more source

Population trends of the fan mussel Pinna nobilis from Portofino MPA (Ligurian Sea, Western Mediterranean Sea) before and after a mass mortality event and a catastrophic storm

The European Zoological Journal, 2021
Two Pinna nobilis populations thriving inside the borders of the Portofino Marine Protected Area (MPA) (Ligurian Sea, western Mediterranean Sea) were monitored before (2012) and after (September 2018) a dire mass mortality event that, since September ...
F. Betti, S. Venturini, L. Merotto, V. Cappanera, S. Ferrando, S. Aicardi, A. Mandich, M. Castellano, P. Povero   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Carp Edema Virus and Cyprinid Herpesvirus-3 Coinfection is Associated with Mass Mortality of Koi (Cyprinus carpio haematopterus) in the Republic of Korea

Pathogens, 2020
As koi and common carp gain importance in the Korean fish industry, the need for better diagnosis, prevention, and treatment of associated diseases has increased. In June 2019, the first known case of mass mortality involving cyprinid herpesvirus-3 (CyHV-
Sang Wha Kim, Sib Sankar Giri, Sang Guen Kim, Jun Kwon, Woo Taek Oh, Se Chang Park   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatiotemporal variation in diabetes mortality in China : multilevel evidence from 2006 and 2012

, 2015
This study was funded by China National Science & Technology Pillar Program 2013(2013BAI04B02) from Ministry of Science and Technology, and The Australia-China Science and Research Fund (ACSRF17120).Background: Despite previous studies reporting spatial ...
Limin Wang, Page, Andrew (R17219), Wang, Limin, Zhou, M., Lijun Wang, Yin, P., Li, Y., Li, Yichong, Liu, Yunning, Wang, L., Peng Yin, Yin, Peng, Andrew Page, Wang, Lijun, Thomas Astell-Burt, Linhong Wang, Liu, J., Astell-Burt, T., Jiangmei Liu, Astell-Burt, Thomas (R16977), Liu, Shiwei, Feng, Xiaoqi, Yunning Liu, Liu, Y., Liu, S., Wang, Linhong, Page, A., Shiwei Liu, Yichong Li, Zhou, Maigeng, Maigeng Zhou, Liu, Jiangmei, Feng, X., Xiaoqi Feng   +33 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source