Results 61 to 70 of about 1,066,264 (303)

Long-term weight loss effects on all cause mortality in overweight/obese populations [PDF]

, 2007
This systematic review assesses the long-term effectiveness of weight loss on all cause mortality in overweight/obese people. Medline, Embase and Cinahl were searched (1966–2005). Cohort studies and trials on participants with Body Mass Index ¡Ý25 kg/m2,
Aucott, Lorna S, Smith, W Cairns S, Avenell, Alison, Boom, John, Jung, Roland, Poobalan, Amudha S   +5 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Epibenthic Invertebrate Diversity on Sublittoral Rocky Habitats in Marine Protected Areas of the North Aegean Sea After a Severe Heatwave Event

Diversity
Marine invertebrates, such as sponges, corals, mollusks and sea squirts, are appropriate climate-change descriptors on sublittoral rocks. The present study assesses the diversity, relative abundance and health condition of epibenthic invertebrates ...
Chryssanthi Antoniadou, Martha Pantelidou, Chariton Chintiroglou   +2 more
doaj   +1 more source

Impact of smoking reduction on coronary heart disease mortality trends during 1981-2000 in England and Wales.

, 2003
OBJECTIVE: To explore how much of the coronary heart disease (CHD) mortality fall in England and Wales can be attributed to changes in smoking prevalence.
S Capewell, Critchley, J, JA Critchley, Unal, B, Capewell, S, B Unal   +5 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Obesity and overweight in relation to disease-specific mortality in men with and without existing coronary heart disease in London: the original Whitehall study

, 2005
Objective: To examine the relations between obesity or overweight and coronary heart disease (CHD) mortality in men with and without prevalent CHD in a prospective cohort study.Methods: In the Whitehall study of London-based male government employees ...
Marmot, MG, Batty, GD, Jarrett, RJ, Barry, GD, Breeze, E, Smith, GD, Davey Smith, G, Shipley, MJ   +7 more
core   +1 more source

Twins and their health cost: consequences of multiple births on parental health and mortality in Denmark and England and Wales. [PDF]

, 2006
The rapid increase in twinning rates in developed countries has increased interest in the question as to whether twin mothers have higher mortality and more health problems than mothers of singletons.
Christensen, Klaare, Emily Grundy, Skytthe, Axel, Axel Skytthe, Tomassini, Cecilia, Kaare Christensen, Cecilia Tomassini, Skytthe, Axel; id_orcid, Grundy, Emily, Christensen, Kaare; id_orcid, Christensen, Kaare   +10 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

A cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in Niger. [PDF]

, 2012
Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6-60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period
Lietman, Thomas, Yu, Sun N, Zhou, Z, Stoller, NE, West, SK, Porco, Travis C, Keenan, JD, Bailey, RL, Gaynor, Bruce D, Amza, Abdou, Kadri, Boubacar, Kadri, B, Nassirou, Baido, Stoller, Nicole E, Mabey, DCW, Amza, A, Bailey, Robin L, Yu, SN, Keenan, Jeremy D, Lietman, Thomas M, West, Sheila K, Keenan, Jeremy, Porco, Travis, Mabey, David CW, Nassirou, B, Zhou, Zhaoxia   +25 more
core   +1 more source