Results 51 to 60 of about 1,053,987 (302)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Estimation of magnitudes of debris flows in selected torrential watersheds in Slovenia
Acta Geographica Slovenica, 2006 In this paper the application of different methods for estimation of magnitudes of rainfall-induced debris flows in 18 torrents in the Upper Sava River valley, NW Slovenia, and in 2 torrents in Pohorje, N Slovenia is described. Additional verification of
Jošt Sodnik, Matjaž Mikoš
doaj +1 more source
Neotectonics and inferred movements in Canada [PDF]
Bulletin of the Geological Society of Finland, 1988 Neotectonic movements in Canada are due to a variety of causes. Within the Canadian Shield (craton) postglacial rebound appears to be the main contributor.
H.S. Hasegawa
doaj +1 more source
From protest to agenda building: Description bias in media coverage of protest events in Washington, D.C [PDF]
, 2001 Social movements often seek to draw attention to issues they deem important by organizing public demonstrations with the aim of attracting mass media coverage. But only a small proportion of all public demonstrations receives any media attention.
Augustyn, B +3 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Социальные (исторические) движения в контексте социологических подходов [PDF]
, 2001 The author analyzes social (historical) movements from various sociological points of view, like positivist, behaviorist and functional ones. There are also discussed the resource mobilization concept and the radical-class approach to the mass movements.
Гавриленко, И.
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Sensitivity equations and calibration requirements on airborne interferometry [PDF]
, 2000 The usage of an airborne interferometric SAR to mass map production is strongly dependent on the capability of performing the data processing in a near automatic mode.
Bara, M +2 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Physio-Géo, 2007 The present work aims to establish relationships between shoreline historical variations (close to the river mouths) and slope dynamics on mountain and hilly areas: these are considered as fundamental physiographic units of the Adriatic central Italy ...
Domenico Aringoli +4 more
doaj +1 more source