Results 141 to 150 of about 12,854,723 (342)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Model Persamaan Massa Karbon Akar Pohon dan Root-Shoot Ratio Massa Karbon (Equation Models of Tree Root Carbon Mass and Root-Shoot Carbon Mass Ratio)

Jurnal Manajemen Hutan Tropika, 2011
The case study was conducted in the area of Acacia mangium plantation at BKPH Parung Panjang, KPH Bogor. The objective of the study was to formulate equation models of tree root carbon mass and root to shoot carbon mass ratio of the plantation.
Elias ., Nyoman Jaya Wistara, Miranti Dewi, Hania Purwitasari   +3 more
doaj   +1 more source

A novel framework for molecular characterization of atmospherically relevantorganic compounds based on collision cross section and mass-to-charge ratio [PDF]

, 2016
Xuan Zhang, Jordan Krechmer, Michael Groessl, Wen Xu, Stephan Gräf, M. J. Cubison, John T. Jayne, J. L. Jiménez, Douglas R. Worsnop, Manjula R. Canagaratna   +9 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Augmenting body mass index and waist-height ratio for establishing more efficient obesity percentiles among school-going children by using body mass index, waist to hip ratio and waist to height ratio

Muller Journal of Medical Sciences and Research, 2014
Background: Traditionally, a fat child is considered as an "attractive" child and is often referred to as a "healthy" child, one who is likely to survive the rigors of undernourishment and infection.
Subhash Shahaji Dhole, Vinod D Mundada
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

On the charge-to-mass ratio for self-gravitating systems of scalar and electromagnetic fields [PDF]

, 2017
P.V. Kratovich, Ju V Tchemarina
openalex   +1 more source

Why Do Elementary Particles Have Such Strange Mass Ratios? - The Role of Quantum Gravity at Low Energies

, 2022
Tejinder Singh
openalex   +2 more sources

Adiabatically compressed wave dark matter halo and intermediate-mass ratio inspirals [PDF]

, 2023
Hyungjin Kim, Alessandro Lenoci, Isak Stomberg, Xiao Xue   +3 more
openalex   +1 more source