MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study. [PDF]
Xie L +6 more
europepmc +1 more source
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Extracellular mass to body cell mass ratio association to nutritional and functional status in middle-aged and older adults. [PDF]
Cano A +10 more
europepmc +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Coronary CT angiography-derived epicardial coronary volume to left ventricular mass ratio associated with myocardial ischemic events in patients with type 2 diabetes mellitus. [PDF]
Wen Z +6 more
europepmc +1 more source
Anticipated correlation between lean body mass to visceral fat mass ratio and insulin resistance: NHANES 2011-2018. [PDF]
Shao Y +5 more
europepmc +1 more source
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
[Total and regional fat-to-muscle mass ratio and risk of incident benign ovarian neoplasm]. [PDF]
Li H, Huang T, Wang L.
europepmc +1 more source

