Results 101 to 110 of about 975,461 (302)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

DIESEL CHARACTERIZATION BY HIGH RESOLUTION MASS SPECTROMETRY-GAS CHROMATOGRAPHY

CT&F Ciencia, Tecnología & Futuro, 1998
High-resolution mass spectrometry-gas chromatography is combined with the HC22 method in order to obtain a detailed information about the chemical composition of diesel and the distribution of different compound types in terms of its final boiling ...
C.A BALDRICHF
doaj  

Assessing Human Treg Suppression at Single-Cell Resolution Using Mass Cytometry

Bio-Protocol
Regulatory T cells (Tregs) are essential for maintaining immune balance by controlling the activation and expansion of other immune cells. Conventional suppression assays often rely on co-culturing purified cell populations, which limits multiplexed ...
Jonas Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James Wing   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Analysis of Ginsenoside Isomers by Inlet Ionization-High Resolution Mass Spectrometry

Zhipu Xuebao
The ginsenoside isomers were analyzed and distinguished by using inlet ionization-high resolution mass spectrometry technology under positive and negative ion modes with optimum inlet temperatures.
Yun-long GUO, Hong-yue CHI, Yang WANG, Fei ZHENG, Yu-lin DAI, Xin HUANG, Hao YUE, Shu-ying LIU   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Urinary Extracellular Vesicles: Potential Biomarkers of Renal Function in Diabetic Patients

Journal of Diabetes Research, 2016
The aim of this study was to check the relationship between the density of urinary EVs, their size distribution, and the progress of early renal damage in type 2 diabetic patients (DMt2).
Agnieszka Kamińska, Mark Platt, Joanna Kasprzyk, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Olga Woźnicka, Benedykt R. Jany, Franciszek Krok, Wojciech Piekoszewski, Marek Kuźniewski, Ewa Ł. Stępień   +10 more
doaj   +1 more source

Monolayer MXene Nanoelectromechanical Piezo-Resonators with 0.2 Zeptogram Mass Resolution. [PDF]

Adv Sci (Weinh), 2022
Tan D, Cao X, Huang J, Peng Y, Zeng L, Guo Q, Sun N, Bi S, Ji R, Jiang C.   +9 more
europepmc   +1 more source

Ultra-fast searching assists in evaluating sub-ppm mass accuracy enhancement in U-HPLC/Orbitrap MS data [PDF]

, 2010
A strategy, detailed methodology description and software are given with which the mass accuracy of U-HPLC-Orbitrap data (resolving power 50,000 FWHM) can be enhanced by an order of magnitude to sub-ppm levels.
J. Efraim Oosterink, Mol, J.G.J., Ruiz-Arcama, A., Ruud J. B. Peters, Arjen Lommen, Oosterink, J.E., Gerssen, A., Harrie J. Kools, Lommen, A., Ainhoa Ruiz-Aracama, Arjen Gerssen, Peters, R.J.B., Kools, H.J., Hans G. J. Mol   +13 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source