Results 81 to 90 of about 975,461 (302)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Innovative solutions for enhanced illicit drugs profiling using comprehensive two-dimensional gas chromatography and mass spectrometry technologies [PDF]

, 2014
This project aimed to determine whether comprehensive two-dimensional gas chromatography is suitable for routine use in a forensic laboratory for profiling illicit substances.
Philip Marriot, Blagoj Mitrevski
core  

Methods for full resolution data exploration and visualization for large 2D and 3D mass spectrometry imaging datasets

, 2014
Mass spectrometry imaging (msi) produces such large amounts of high-resolution data that fast visualization of full data sets in both high spatial and spectral resolution is often problematic.
Chughtai, Kamila, Ellis, Shane R., Heeren, Ron M. A., Klinkert, Ivo   +3 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Automated, parallel mass spectrometry imaging and structural identification of lipids [PDF]

, 2018
We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment.
Mark W. Jervelund, Heeren, Ron M. A., Peter Husen, Ejsing, Christer S.; id_orcid, Eijkel, Gert B., Josch K. Pauling, Hermansson, Martin, Jervelund, Mark W., Heeren, Ron M.A., Ron M. A. Heeren, Shane R. Ellis, Martin Hermansson, Martin R. L. Paine, Ellis, Shane R., Christer S. Ejsing, Ejsing, Christer S., Paine, Martin R.L., Husen, Peter, Gert B. Eijkel, Paine, Martin R. L., Pauling, Josch K.   +20 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The development of a high resolution mass spectrometer: A reminiscence [PDF]

Journal of the American Society for Mass Spectrometry, 1991
This article is a review of the events leading to the development of the double-focusing tandem mass spectrometer system, which is sometimes called the Johnson-Nier geometry. An essential feature of the geometry is that it eliminates second-order angular aberration, enhancing the sensitivity, without a loss in resolution.
openaire   +2 more sources

High-Resolution Integrated Microfluidic Probe for Mass Spectrometry Imaging of Biological Tissues

, 2023
Nanospray desorption electrospray ionization (nano-DESI) is an ambient ionization technique that enables molecular imaging of biological samples with high spatial resolution.
Hang, Hu, Julia, Laskin, Xiangtang, Li
core   +1 more source