Results 91 to 100 of about 6,872,930 (361)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cancer Medicine, 2020 Background Immunocytochemical staining with p16/Ki67 has been suggested as a promising triage biomarker in cervical cancer screening. As dual staining is a subjective method, proper training may be required to ensure safe implementation in routine ...
Anne Hammer +6 more
doaj +1 more source
Fluorine Mass Balance and Suspect Screening in Marine Mammals from the Northern Hemisphere
Environmental Science and Technology, 2019 There is increasing evidence that the ∼20 routinely monitored perfluoroalkyl and polyfluoroalkyl substances (PFASs) account for only a fraction of extractable organofluorine (EOF) occurring in the environment.
Kyra M. Spaan +13 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Quadrupole Time-of-Flight Mass Spectrometry: A Paradigm Shift in Toxicology Screening Applications.
Clinical biochemist reviews, 2019 The screening of biological samples for the presence of illicit or legal substances is an important frontline tool in both clinical and forensic toxicology.
Darren R Allen, B. McWhinney
semanticscholar +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
대한영상의학회지, 2017 Purpose: To survey medical institutions in Korea that conduct chest low-dose computed tomography (LDCT) scan prior to introduction of the national lung cancer screening (LCS) project.
Jae Gu Oh +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Lie Groups of Partial Differential Equations and Their Application to the Multidimensional Screening Problems [PDF]
In this paper I describe group theoretic methods that can be used for analyzing the boundary problems, which arise when the Hamiltonian method is applied to solve the relaxed problem for the multidimensional screening problem.
Suren Basov
core +2 more sources
The first case with propionic acidemia found in newborn screening by tandem mass spectrometry in Japan : clinical management during infancy [PDF]
, 2000 The purpose of this study was to clarify the factors which influence the efficacy of treatment on a patient with propionic acidemia who was found in our pilot study of newborn screening by tandem mass spectrometry.
眞弓, 光文 +15 more
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