Results 81 to 90 of about 6,872,930 (361)

The optimal cut‐off value in fit‐based colorectal cancer screening: An observational study

open access: yesCancer Medicine, 2021
Background Colorectal cancer (CRC) screening programs using fecal immunochemical test (FIT) have to choose a cut‐off value to decide which citizens to recall for colonoscopy. The evidence on the optimal cut‐off value is sparse and based on studies with a
Sisse Helle Njor   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Direct Screening of a Dynamic Combinatorial Library Using Mass Spectrometry

open access: yes, 2006
A dynamic combinatorial library (DCL) screening approach is described that permits direct identification of the effective (from ineffective) combination of building blocks in the equilibrating DCL.
Poulsen, Sally-Ann
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Prostate Cancer Screening and Health Beliefs: A Turkish Study of Male Adults

open access: yesErciyes Medical Journal, 2019
Objective: Attitudes and beliefs of people affect health behaviors. Understanding the individual experiences with regard to prostate cancer (PCa) and PCa screening of the participants is important.
Naile Bilgili, Yeter Kitiş
doaj   +1 more source

High resolution mass spectrometry-based non-target screening can support regulatory environmental monitoring and chemicals management

open access: yesEnvironmental Sciences Europe, 2019
Non-target screening (NTS) including suspect screening with high resolution mass spectrometry has already shown its feasibility in detecting and identifying emerging contaminants, which subsequently triggered exposure mitigating measures. NTS has a large
J. Hollender   +15 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Cost-effectiveness Analysis of a Two-stage Screening Intervention for Hepatocellular Carcinoma in Taiwan

open access: yesJournal of the Formosan Medical Association, 2010
Hepatocellular carcinoma (HCC) has been the leading cause of cancer death in Taiwan since the 1980s. A two-stage screening intervention was introduced in 1996 and has been implemented in a limited number of hospitals. The present study assessed the costs
Sophy Ting-Fang Shih   +2 more
doaj   +1 more source

AI for public health: Self-screening for eye diseases

open access: yes, 1998
A software-based visual-field testing (perimetry) system is described which incorporates several AI components, including machine learning, an intelligent user interface and pattern discovery.
Liu, X   +5 more
core   +1 more source

Mass Activated Droplet Sorting (MADS) Enables High Throughput Screening of Enzymatic Reactions at Nanoliter Scale.

open access: yesAngewandte Chemie, 2019
Microfluidic droplet sorting enables the high throughput screening and selection of water-in-oil microreactors at speeds and volumes unparalleled by traditional well-plate approaches.
Daniel A Holland-Moritz   +10 more
semanticscholar   +1 more source

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