Screening for obstructive sleep apnea in elderly: performance of the Berlin and STOP-Bang questionnaires and the Epworth sleepiness scale using polysomnography as gold standard [PDF]
Sleep Science, 2022 Objectives: Obstructive sleep apnea (OSA) affects approximately one third of the population and can reach 90% prevalence in the elderly. There are screening tools to track the disease, however, their performance may differ according to population ...
Paulo Henrique Godoy +4 more
doaj +1 more source
Evaluation of the Results of Services Provided in Breast Cancer Counseling and Screening Clinics in Babol, 2012-2017 [PDF]
Journal of Health Sciences and Surveillance System, 2023 Background: Successful treatment of breast cancer (BC) depends on its early detection, which has a significant role in reducing its mortality. The purpose of this study was to evaluate the services provided and the results in women referred to Babol ...
Fatemeh Jafari +9 more
doaj +1 more source
Advances in high‐throughput mass spectrometry in drug discovery
EMBO Molecular Medicine, 2022 High‐throughput (HT) screening drug discovery, during which thousands or millions of compounds are screened, remains the key methodology for identifying active chemical matter in early drug discovery pipelines.
Maria Emilia Dueñas +5 more
doaj +1 more source
Multi-omics to predict changes during cold pressor test
BMC Genomics, 2022 Background The cold pressor test (CPT) is a widely used pain provocation test to investigate both pain tolerance and cardiovascular responses. We hypothesize, that performing multi-omic analyses during CPT gives the opportunity to home in on molecular ...
Lisette J. A. Kogelman +9 more
doaj +1 more source
Multi-omic analyses of triptan-treated migraine attacks gives insight into molecular mechanisms
Scientific Reports, 2023 Migraine is a common, polygenic disorder that is characterized by moderate to severe headache attacks. Migraine attacks are commonly treated with triptans, i.e. serotonin receptor agonists.
Lisette J. A. Kogelman +10 more
doaj +1 more source
Material Screening with Mass Spectrometry
Physics, 2021 Inductively coupled plasma mass spectrometry is a powerful analytical technique. Because of its sensitivity, accuracy, multielement capability, high throughput, rapid analysis times and low detection limits, it is able to determine simultaneously long ...
Francesca Marchegiani +2 more
doaj +1 more source
BMC Research Notes, 2022 Objective We developed an assay to measure the concentration of 25 hydroxyvitamin D2 and D3 in protein extracts derived from stored neonatal dried blood spots.
Sanne Grundvad Boelt +5 more
doaj +1 more source
Deep Neural Network-Based Prediction of the Risk of Advanced Colorectal Neoplasia
Gut and Liver, 2021 Background/Aims: Risk prediction models using a deep neural network (DNN) have not been reported to predict the risk of advanced colorectal neoplasia (ACRN). The aim of this study was to compare DNN models with simple clinical score models to predict the
Jun Ki Min +8 more
doaj +1 more source
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study
Scientific Reports, 2021 Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention ...
João Fadista +17 more
doaj +1 more source
Bioaffinity Mass Spectrometry Screening [PDF]
SLAS Discovery, 2016 Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS or ESI-FTMS) was used to screen 192 natural product extracts and a 659-member natural product-based fragment library for bindings to a potential malaria drug target, Plasmodium falciparum Rab11a (PfRab11a, PF13_0119).
Yang, Ben +9 more
openaire +5 more sources