Results 41 to 50 of about 416,822 (244)

Microscopes and Mass Spectrometers [PDF]

Journal of Proteomics & Bioinformatics, 2016
Proteomics is a relatively young discipline while pathology is one of the oldest forms of scientific inquiry. These two fields have different methods and aims, but have many areas of overlap and shared interests. Cultivation of synergistic projects between physicians who study static images of disease and biologists who study the dynamic environment ...
Shields, Bradley, Shalin, Sara C, Tackett, Alan J   +2 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

In-situ mass-spectrometer of magnetized plasmas

Nuclear Materials and Energy, 2017
Modified mass-spectrometer of magnetized plasmas (MSMP-03) was installed on the linear plasma device PSI-2 in support of plasma-material interaction studies.
I.A. Sorokin, I.V. Vizgalov, V.A. Kurnaev, C. Brandt, A. Kreter, Ch. Linsmeier   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Miniature MEMS Mass Spectrometer for Space Applications [PDF]

Przegląd Komunikacyjny
: The article describes a miniature mass spectrometer made at the Wroclaw University of Science and Technology in cooperation with Creotech Instruments for of the European Space Agency.
Piotr Szyszka, Tomasz Grzebyk
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Measurement of the Elemental Composition of Materials by Electron Mass Spectrum [PDF]

Журнал нано- та електронної фізики, 2016
The work is concerned with a multichannel detector consisting of mass spectrometer that implements the functions of registration, generation of ion-electron avalanche and giving out information about their number in each channel in the form of logical ...
A.V. Kosulya, V.G. Verbitskiy
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Peregrine Ion Trap Mass Spectrometer (PITMS): Results from a CLPS-delivered Mass Spectrometer

The Planetary Science Journal
The Peregrine Ion Trap Mass Spectrometer (PITMS) was a mass spectrometer designed to measure lunar gases. PITMS flew on the first flight of Astrobotic’s Peregrine lander via the Commercial Lunar Payload Services (CLPS) program in 2024 January.
Barbara A. Cohen, Simeon J. Barber, Aleksandra J. Gawronska, Feargus A. J. Abernethy, Natalie M. Curran, Phillip A. Driggers, William M. Farrell, David J. Heather, Christopher Howe, Peter F. Landsberg, Veneranda López-Días, Andrew D. Morse, Thomas Morse, Michael J. Poston, Parvathy Prem, Roland Trautner, Orenthal J. Tucker, Tristram J. Warren, Stefano Boccelli   +18 more
doaj   +1 more source