Results 61 to 70 of about 461,051 (310)

In-situ mass-spectrometer of magnetized plasmas

Nuclear Materials and Energy, 2017
Modified mass-spectrometer of magnetized plasmas (MSMP-03) was installed on the linear plasma device PSI-2 in support of plasma-material interaction studies.
I.A. Sorokin, I.V. Vizgalov, V.A. Kurnaev, C. Brandt, A. Kreter, Ch. Linsmeier   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Droplet activation, separation, and compositional analysis: laboratory studies and atmospheric measurements

, 2011
Droplets produced in a cloud condensation nuclei chamber (CCNC) as a function of supersaturation have been separated from unactivated aerosol particles using counterflow virtual impaction.
Cziczo, Daniel J., Pekour, Mikhail S., Kohn, Monika, Shilling, John E., Nelson, Danny A., Hiranuma, Naruki   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

High-Resolution Mass Spectrometer–Based Ultra-Deep Profile of Milk Whey Proteome in Indian Zebu (Sahiwal) Cattle

Frontiers in Nutrition, 2020
Milk serves as a mode of protection to neonate through transferring the host defense proteins from mother to offspring. It also guards the mammary gland against various types of infections. Along with the presence of six vital proteins, bovine milk (whey)
Alka Chopra, Syed Azmal Ali, Shveta Bathla, Preeti Rawat, Vikas Vohra, Sudarshan Kumar, Ashok Kumar Mohanty   +6 more
doaj   +1 more source

A Constant-Momentum/Energy-Selector Time-of-Flight Mass Spectrometer

, 2007
A matrix assisted laser desorption/ionization time-of-flight mass spectrometer has been built with an ion source that can be operated in either constant-energy or constant-momentum acceleration modes.
Håkansson, Per,, Barofsky, D. F., Piyadasa, C.K.G., Santacruz, C.P., Håkansson, P., Barofsky, D.F., Piyadasa, C. K. G.   +6 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Peregrine Ion Trap Mass Spectrometer (PITMS): Results from a CLPS-delivered Mass Spectrometer

The Planetary Science Journal
The Peregrine Ion Trap Mass Spectrometer (PITMS) was a mass spectrometer designed to measure lunar gases. PITMS flew on the first flight of Astrobotic’s Peregrine lander via the Commercial Lunar Payload Services (CLPS) program in 2024 January.
Barbara A. Cohen, Simeon J. Barber, Aleksandra J. Gawronska, Feargus A. J. Abernethy, Natalie M. Curran, Phillip A. Driggers, William M. Farrell, David J. Heather, Christopher Howe, Peter F. Landsberg, Veneranda López-Días, Andrew D. Morse, Thomas Morse, Michael J. Poston, Parvathy Prem, Roland Trautner, Orenthal J. Tucker, Tristram J. Warren, Stefano Boccelli   +18 more
doaj   +1 more source

Analysis and Evaluation of Imperfect Harmonic Potential in Orbitrap

Zhipu Xuebao
Orbitrap mass analyzer is renowned for its capability to confine charged particles stably and precisely determine their mass-to-charge ratios via a unique electrostatic field generated by spindle-shaped electrodes.
Yu-ze ZHAO, Bing-sheng TU
doaj   +1 more source