Results 61 to 70 of about 3,845,991 (260)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
High-resolution mass spectrometry and velocity map imaging for ultrafast electron dynamics in complex biomolecules [PDF]
EPJ Web of Conferences, 2019 We present a design combining a velocity map imaging electron spectrometer with a reflectron mass spectrometer. Since the two spectrometer sides have different intrinsic requirements for the electric field in the central region, a large number of ...
Månsson Erik P. +7 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Peregrine Ion Trap Mass Spectrometer (PITMS): Results from a CLPS-delivered Mass Spectrometer
The Planetary Science JournalThe Peregrine Ion Trap Mass Spectrometer (PITMS) was a mass spectrometer designed to measure lunar gases. PITMS flew on the first flight of Astrobotic’s Peregrine lander via the Commercial Lunar Payload Services (CLPS) program in 2024 January.
Barbara A. Cohen +18 more
doaj +1 more source
Analysis and Evaluation of Imperfect Harmonic Potential in Orbitrap
Zhipu XuebaoOrbitrap mass analyzer is renowned for its capability to confine charged particles stably and precisely determine their mass-to-charge ratios via a unique electrostatic field generated by spindle-shaped electrodes.
Yu-ze ZHAO, Bing-sheng TU
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A Constant-Momentum/Energy-Selector Time-of-Flight Mass Spectrometer [PDF]
, 2007 A matrix assisted laser desorption/ionization time-of-flight mass spectrometer has been built with an ion source that can be operated in either constant-energy or constant-momentum acceleration modes.
Håkansson, Per, +3 more
core +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source