Results 51 to 60 of about 610,359 (296)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Crowdsourcing Public Perceptions of Plastic Surgeons: Is There a Gender Bias?

Plastic and Reconstructive Surgery, Global Open, 2018
Background:. Implicit gender bias may result in lower wages for women, fewer leadership positions, and lower perceived competence. Understanding public and patient gender preferences for plastic surgeons may enable opportunities to address public ...
Alexandra Bucknor, MBBS, MSc, MRCS, Joani Christensen, MD, Parisa Kamali, MD, Sabine Egeler, MD, Charlotte van Veldhuisen, BSc, Hinne Rakhorst, MD, PhD, Irene Mathijssen, MD, PhD, Samuel J. Lin, MD, MBA, FACS, Heather Furnas, MD, FACS   +8 more
doaj   +1 more source

Suppression of Interference of Fixative With Odorant Samples in Mass Spectrum Using ICA

IEEE Access, 2021
Odor sensing enables us to sense odorant stimuli. This sensation causes a deep subconscious response in humans in various ways and represents an indispensable sensation in daily life.
Dani Prasetyawan, Takamichi Nakamoto
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Bound Electron Enhanced Radiosensitisation of Nimorazole upon Charge Transfer

Molecules, 2022
This novel work reports nimorazole (NIMO) radiosensitizer reduction upon electron transfer in collisions with neutral potassium (K) atoms in the lab frame energy range of 10–400 eV.
Sarvesh Kumar, Islem Ben Chouikha, Boutheïna Kerkeni, Gustavo García, Paulo Limão-Vieira   +4 more
doaj   +1 more source

On mass spectrum in SQCD. Unequal quark masses [PDF]

Journal of Experimental and Theoretical Physics, 2010
17 pages, small improvements; also replaced the paper arXiv:0712.3167, with significant ...
openaire   +3 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors

Biological Procedures Online, 2002
There is accumulating evidence that membrane-bound receptors interact with many intracellular proteins. Multiprotein complexes associated with ionotropic receptors have been extensively characterized, but the identification of proteins interacting with G
Bécamel Carine, Galéotti Nathalie, Poncet Joël, Jouin Patrick, Dumuis Aline, Bockaert Joël, Marin Philippe   +6 more
doaj   +1 more source

Drug Content Uniformity: Quantifying Loratadine in Tablets Using a Created Raman Excipient Spectrum

Pharmaceutics, 2021
Raman spectroscopy has proven valuable for determining the composition of manufactured drug products, as well as identifying counterfeit drugs. Here we present a simple method to determine the active pharmaceutical ingredient (API) mass percent in a ...
Amelia Farquharson, Zachery Gladding, Gary Ritchie, Chetan Shende, Joseph Cosgrove, Wayne Smith, Carl Brouillette, Stuart Farquharson   +7 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source