Results 61 to 70 of about 2,871,177 (303)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Numerical stability of mass transfer driven by Roche lobe overflow in close binaries

, 2005
Numerical computation of the time evolution of the mass transfer rate in a close binary can be and, in particular, has been a computational challenge. Using a simple physical model to calculate the mass transfer rate, we show that for a simple explicit ...
A. Büning, Beer, Benvenuto, Boccaletti, Büning, D'Antona, D'Antona, de Sousa Vieira, Feigenbaum, Feigenbaum, H. Ritter, Hameury, Hjellming, Kippenhahn, Kolb, Kolb, Li, Ott, Paczynski, Pyragas, Ritter, Sarna, Schenker, Socolar, Tout   +24 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Scalability of mass transfer in Taylor flow in capillaries [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Kuhn, S, Nappo, V   +2 more
core  

Orbital Evolution of Compact White Dwarf Binaries

, 2012
The new-found prevalence of extremely low mass (ELM ...
Badenes, Bildsten, Brown, Brown, D'Antona, David L. Kaplan, Deloye, Eisenstein, Hansen, Israel, Justin D. R. Steinfadt, Kalirai, Kasliwal, Kawka, Kilic, Kilic, Kilic, Kilic, Kilic, Kilic, Kulkarni, Landau, Lars Bildsten, Levitan, Marsh, Marsh, Marsh, Mullally, Nomoto, Paczyński, Papaloizou, Parsons, Paxton, Roelofs, Shen, Steinfadt, Steinfadt, Strohmayer, Strohmayer, Strohmayer, Tutukov, van Kerkwijk, van Kerkwijk, Vennes   +43 more
core   +1 more source

Influence of electrostatic interactions in electrophoretic membrane contactors [PDF]

, 2002
In electrophoretic separators, a porous membrane is used to put into contact two flowing liquids between which an electrically driven mass transfer takes place. As far as charged solutes are concerned, the mass transfer can be affected by electrostatic
Galier, Sylvain, Roux-de Balmann, Hélène   +1 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Additives to Coal-Based Fuel Pellets for the Intensification of Combustion and Reduction in Anthropogenic Gas Emissions

Applied Sciences, 2020
Cylinder-shaped fuel pellets that were 3 mm in diameter and 3 mm in height, with a mass of 20 mg, were produced by compressing dry coal processing waste under the pressure of 5 MPa. The first group of pellets from coal dust with a particle size less than
Dmitriy Klepikov, Tereza Kudelova, Kristina Paushkina, Pavel Strizhak   +3 more
doaj   +1 more source