Results 61 to 70 of about 5,885,787 (255)
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Saturation dependence of mass transfer for solute transport through residual unsaturated porous media [PDF]
The residual non-wetting phase in unsaturated porous media varies the aqueous pore space due to the immiscible characteristics. The varied pore space in turn has significant influence on the mass transfer for aqueous tracer transport through residual ...
Zhang, Xueyi (author) +5 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The influence of return bends on the downstream pressure drop and condensation heat transfer in tubes [PDF]
The influence of return bends on the downstream pressure drop and heat transfer coefficient of condensing refrigerant R-12 was studied experimentally. Flow patterns in glass return bends of 1/2 to 1 in. radius and 0.315 in. I. D.
Traviss, Donald P., Rohsenow, Warren M.
core
Containment and Suppression of Class A Fires Using CO2 Hydrate
This paper presents the experimental findings on fire containment and suppression by dropping CO2 hydrate granules and tablets on burning solid materials.
Olga Gaidukova +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The system of measuring of the temperature fields distributing, constructed on the basis of digital camera-recorder, is considered. It is shown that the system has advantages as compared to traditional thermal-imaging sets on receivers, operating in ...
I. V. Fain +3 more
doaj
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
COMPLEX INVESTIGATIONS OF THERMALPHYSIC AND INFRA-RED CHARACTERISTICS AT THE PHASE INVERSIONS
The complex methods of investigation of heat exchange at crystallization and melting of selectively transparent materials in terms of changing of external heat influences, which include calorimetry of IK-currents, temperature taking, the heat conduction ...
V. L. Dragun +3 more
doaj
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source

