Results 71 to 80 of about 225,767 (306)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Propagation and deposition of stony debris flows at channel confluences [PDF]

, 2015
The fluid dynamics of stony debris flows generated in two small tributaries adjacent to each other and flowing into a main receiving channel was analyzed experimentally at a laboratory scale.
Foti, E., Lanzoni, Stefano, Stancanelli, LAURA MARIA   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pattern formation during the evaporation of a colloidal nanoliter drop: a numerical and experimental study

, 2010
An efficient way to precisely pattern particles on solid surfaces is to dispense and evaporate colloidal drops, as for bioassays. The dried deposits often exhibit complex structures exemplified by the coffee ring pattern, where most particles have ...
, , Attinger D, Bhardwaj R, Bird R B, Burnett D S, Daniel Attinger, deGennes P G, Fuchs N A, Gillen G, Goodwin R D, Haferl S, Heim T, Krishna P, Lide D R, Maxwell J C, Ondarcuhu T, Popov Y, Rajneesh Bhardwaj, VanWylen G J, Vargaftik N B, Xiaohua Fang, Xu J Attinger D, Zheng R   +23 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

An Adapted Rotating Disk Electrode Setup to Test Nonstandard‐Disk Electrodes: On the Enhanced Hydrogen Evolution Performance of Model Dewetted Pt Nanoparticles Versus Pt Thin Films under Hydrodynamic Conditions

ChemElectroChem
A common approach to test electrocatalyst nanoparticles (NPs) for electrolyzers and fuel cells is to deposit catalyst particles (e.g., Pt/carbon) onto standard disk electrodes (e.g., glassy carbon) by making use of inks based on binders (ionomers such as
Shreyas Harsha, Lasse Wichmann, Guido Mul, Marco Altomare   +3 more
doaj   +1 more source

True Volumes of Slope Failure Estimated From a Quaternary Mass‐Transport Deposit in the Northern South China Sea

Geophysical Research Letters, 2018
Submarine slope failure can mobilize large amounts of seafloor sediment, as shown in varied offshore locations around the world. Submarine landslide volumes are usually estimated by mapping their tops and bases on seismic data.
Qiliang Sun, Tiago M. Alves, Xiangyang Lu, Chuanxu Chen, Xinong Xie   +4 more
doaj   +1 more source

A Channel Network Model for Sediment Dynamics Over Watershed Management Time Scales

Journal of Advances in Modeling Earth Systems, 2020
A mountain watershed network model is presented for use in decadal to centurial estimation of source‐to‐sink sediment dynamics. The model requires limited input parameters and can be effectively applied over spatial scales relevant to management of ...
Claire Beveridge, Erkan Istanbulluoglu, Christina Bandaragoda, Allison M. Pfeiffer   +3 more
doaj   +1 more source

Effect of Shell Thickness on Electron and Hole Transmission Probabilities of a ZnSe/ZnS Core- Shell Quantum Dot [PDF]

Materials Research, 2018
In this paper we report the effect of shell thickness on transmission probabilities of electrons and holes in the strained configuration of zinc-selenide/zinc-sulphide (ZnSe/ZnS) core-shell quantum dot.
Bashir Mohi Ud Din Bhat, Khurshed A. Shah   +1 more
doaj   +1 more source

Experimental Study on Aerosol Removal Characteristics from Wall Surfaces in Condensation Wash-down Environment

Yuanzineng kexue jishu, 2023
For the nuclear reactor that experienced a severe radioactive leakage accident, there will be radioactive aerosols dispersed in vapor phase space of the containment vessel.
SUN Qingyang1;GU Haifeng1,*;LI Jingjing2;ZHOU Yanmin1;ZHANG Zhigang1;WANG Xiao1;E Xinnuo1;LI Tao1
doaj   +1 more source