Results 131 to 140 of about 271,644 (300)

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

La vacunación antisarampionosa en México por el método de aerosol

Salud Pública de México, 1997
En este trabajo se describen las acciones de vacunación contra el sarampión por el método de aerosol inhalado llevadas a cabo en la República Mexicana entre 1988 y 1990.
JORGE FERNÁNDEZ-DE CASTRO, JESÚS KUMATE- RODRÍGUEZ, JAIME SEPÚLVEDA, JOSÉ MANUEL RAMÍREZ- ISUNZA, JOSÉ LUIS VALDESPINO-GÓMEZ   +4 more
doaj  

Experiences and Lessons Learned from the Measles-Rubella Vaccination Campaign 2023 Implemented in Private Schools of Kolkata

Indian Journal of Community Medicine
Background: Measles-Rubella vaccination campaign (MRVC) was conducted in West Bengal with a target to achieve more than 95% vaccination among children aged 9 months to 15 years.
Poulomi Mukherjee, Mousumi Datta, Arup Chakraborty, Debasis Das   +3 more
doaj   +1 more source

COVID-19 mass vaccination - an illustration of the impact of syringe choice on the effectiveness of mass vaccination campaigns. [PDF]

Emerg Microbes Infect, 2022
Roseline M, Luc C, Julien L, Olivier E, Etienne B, Pierrick B.   +5 more
europepmc   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Public health impact of herpes zoster vaccination on older adults in Singapore: a modeling study

Human Vaccines & Immunotherapeutics
In Singapore, population aging and rising life expectancy are increasing herpes zoster (HZ) burden, which may be reduced by vaccination. The present study modeled the public health impact of HZ vaccination in Singapore using ZOster ecoNomic Analysis ...
Helen Oh, Carol Tan, Charles Williams, Nikolaos Giannelos, Cheryl Ng   +4 more
doaj   +1 more source

COVID-19 vaccination hesitancy and challenges to mass vaccination [PDF]

Hong Kong Medical Journal, 2021
openaire   +2 more sources

Neonatal azithromycin administration to prevent infant mortality: study protocol for a randomised controlled trial. [PDF]

, 2019
IntroductionBiannual mass azithromycin distribution to children aged 1-59 months has been shown to reduce all-cause mortality. Children under 28 days of age were not treated in studies evaluating mass azithromycin distribution for child mortality due to ...
Bagagnan, Cheik, Bountogo, Mamadou, Brogdon, Jessica, Coulibaly, Boubacar, Doan, Thuy, Godwin, William W, Lebas, Elodie, Lietman, Thomas M, Lin, Ying, NAITRE Study Group, Nebie, Eric, Oldenburg, Catherine E, Ouattara, Mamadou, Porco, Travis, Sie, Ali, Zabre, Pascal   +15 more
core  

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source