Results 101 to 110 of about 2,600,664 (305)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Mombasa Gate City Master Plan 2022: A Premier Gateway Port City That Upholds Diversity and Heritage
, 2022 Mombasa County is located in the strategic location within the Northern Economic Corridor (NEC) which connects Mombasa to the rest of East African nations. NEC is the most significant multi-modal corridor in East Africa.
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
PECULIARITIES OF PREPARATION OF FUTURE SOFTWARE ENGINEER FOR PEDAGOGICAL ACTIVITY
Ìнформаційні технології в освіті, 2015 The article shows the main results of the study of the current state of the system of masters training in information technology in higher education institutions, including the analysis of interim educational and vocational programs of specialist and ...
V. Sedov
doaj
Other title: Educational and training requirements of the Kansas economy to 1985
, 1971 Title from cover.; "The Master Planning Commission on Kansas education created by the 1970 Kansas Legislature, met for the first time in April, 1970, in Topeka. Its mission is to prepare the first phase of an educational master plan for Kansas.
Kansas. Master Planning Commission.
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A method for clustering surgical cases to allow master surgical scheduling [PDF]
Master surgical scheduling can improve manageability and efficiency of operating room departments. This approach cyclically executes a master surgical schedule of surgery types.
Oostrum, J.M. van +3 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source