Results 131 to 140 of about 5,533,367 (371)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Bibliometric profile of graduate theses regarding “Medical and aromatic plants” in Türkiye

open access: yesTurkish Journal of Forestry
In this study, it is aimed to reveal the bibliometric profile of graduate (master's and doctorate) studies written on "Medical and Aromatic Plants" in Türkiye in terms of various criteria.
İlker Akyüz, Nadir Ersen
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Digital Competence in the Master’s Degree in Training for Teachers: The Influence of Academic and Emotional Factors on Its Development

open access: yesEducation Sciences
Digital Competence (DC) is relevant among approaches aimed at educational innovation in the digital society. This work analyses the DC level of students of the Master’s Degree in Training for Teachers in a University of the Basque Country, and identifies
Estibaliz Cepa-Rodriguez   +1 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Le masque de Socrate dans le théâtre du monde d’Épictète-Arrien

open access: yesAitia, 2022
Arrian is the only person responsible for Epictetus’ Dissertationes as a literary work. He adopts the strategy of the disciple who makes himself invisible to better ensure the effectiveness of his master’s speeches.
Pedro Pablo Fuentes González
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

PECULIARITIES OF PREPARATION OF FUTURE SOFTWARE ENGINEER FOR PEDAGOGICAL ACTIVITY

open access: yesÌнформаційні технології в освіті, 2015
The article shows the main results of the study of the current state of the system of masters training in information technology in higher education institutions, including the analysis of interim educational and vocational programs of specialist and ...
V. Sedov
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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