Results 91 to 100 of about 2,704,777 (296)

Quantifying Stress and Relaxation: A New Measure of Heart Rate Variability as a Reliable Biomarker

Biomedicines
Background/Objectives: For the rapid, objective characterization of the physiological stress response, there is currently no generally recognized standard.
Emese Rudics, András Buzás, Antónia Pálfi, Zoltán Szabó, Ádám Nagy, Emőke Adrienn Hompoth, József Dombi, Vilmos Bilicki, István Szendi, András Dér   +9 more
doaj   +1 more source

Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management. [PDF]

Comput Methods Programs Biomed, 2021
Akkoyun E, Gharahi H, Kwon ST, Zambrano BA, Rao A, Acar AC, Lee W, Baek S.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Temperature and Speed Corrections for TSD-Measured Deflection Slopes Using 3D Finite Element Simulations

Infrastructures
Traffic Speed Deflectometer (TSD) measures deflection velocities, normalised by travel speed to obtain deflection slopes. Pavement temperature and travel speed can significantly affect deflection slopes.
Nariman Kazemi, Mofreh Saleh, Chin-Long Lee   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Two Origins for Bell-Shaped Velocity-Dependent Friction Coefficient: Kelvin-Voigt or Standard Linear Solid Viscoelasticity

Tribology Online
It is well known that the friction coefficient of viscoelastic solids against the drive speed exhibits a bell shape. In previous theoretical studies on viscoelastic friction, we can find two origins for the bell shape. One is due to the material response
Toshiki Watanabe, Ken Nakano
doaj   +1 more source

New prediction technique of master curve of rubber material from the data by dynamic mechanical analyzer

Nihon Kikai Gakkai ronbunshu, 2016
A new prediction technique of master curve from limited data measured under temperature variance and constant frequency in a dynamic measurement tester has been proposed.
Naruto MAEDA, Masaki FUJIKAWA, Tatsujiro MIYAZAKI, Chobin MAKABE, Junichiro YAMABE, Masataka KOISHI   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Video (sound only, no image) of a man remembering taking part in a play at Curve

, 2014
A video (duration 34 seconds) with the image blanked out , the audio is a man talking about his positive memories of taking part in the play "East" by Stephen Berkoff at Curve, directed by Paul Kerryson, and how the experience influenced his future.When ...
Anonymous;
core