Results 131 to 140 of about 167,547,701 (297)

The State of Mastery Learning in Pediatric Graduate Medical Education: A Scoping Review [PDF]

Michaela Mills-Rudy,1 Megan Thorvilson,1 Cynthia Chelf,2 Stephanie Mavis3 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; 2Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 3Department of Pediatric and ...
Chelf C, Mills-Rudy M, Mavis S, Thorvilson M   +3 more
core  

Peran Pembelajaran Berbasis Masalah terhadap Penguasaan Konsep dan Tanggung Jawab Siswa Kelas IV pada Materi Daerahku dan Kekayaan Alamnya

Edukasia
The low understanding ability of students in learning science and science is the main factor in conducting this research. This is due to the lack of meaningfulness in science learning. This research aims to determine the increase in students' mastery of
Erin Giri Arum, Atep Sujana, I. Isrokatun   +2 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

How can digital media enhance students\u27 mastery of threshold concepts? [PDF]

Mastery of threshold concepts is driven by students’ expanding knowledge and experience. Threshold concepts cannot be taught via the simple transfer of knowledge, but instead ‘emerge’ for students via experience, conceptualisation and self-development ...
Knowles, Nicola, Jones, Edwina
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The roles of basic psychological needs, self-compassion, and self-efficacy in the development of mastery goals among medical students

, 2019
Aim: Competency-based medical education aims to foster mastery goals in learners. We examined medical students’ mastery approach (beneficial) and mastery avoidance (maladaptive) goals and their associations with students’ basic psychological needs, self ...
Babenko, Oksana, Oswald, Anna
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The mastery of Malay language among Tamil school students [PDF]

This analysis centers on characterizing the degree of verbal mastery of the verb in the Malay language using the questionnaire by Tamil school students.
Abdul Jabar, Mohd Azidan, Husain, Salina, Munuyandi, Thulasirani, Jusoh, Zuraini   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Generic Skills: Concept and Importance of Students Mastery [PDF]

International Journal of Academic Research in Progressive Education and Development, 2019
Maizatul Suraya Muhammad Nor, Mohd Isa Hamzah, Khadijah Abdul Razak, Fatahiyah Elias   +3 more
openaire   +1 more source