Results 91 to 100 of about 2,109 (292)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Oak masting drivers vary between populations depending on their climatic environments

, 2023
Large interannual variation in seed production, called masting, is very common in wind-pollinated tree populations and has profound implications for the dynamics of forest ecosystems and the epidemiology of certain human diseases. 1 ,2 ,3 ,4 ,5 Comparing
BOULANGER, Vincent, CAIGNARD, Thomas, DÉBIAS, François, LOBRY, Jean R, Thomas Caignard, MERMET-BOUVIER, Camille, Jean R. Lobry, FLEUROT, Emilie, VENNER, Samuel, Sylvain Delzon, François Debias, BEL-VENNER, Marie-Claude, Marie-Claude Bel-Venner, Vincent Boulanger, Samuel Venner, DELZON, Sylvain, Emilie Fleurot, Camille Mermet-Bouvier   +17 more
core   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

The plasticity of masting: understanding how and why temporal reproductive patterns vary in trees [PDF]

Long-lived plants like trees often exhibit highly variable, yet synchronised reproduction, commonly referred to as ‘masting’. The boom-and-bust patterns of seed production have complex and far-reaching effects on regeneration and food webs. Understanding
Foest, Jessie
core   +1 more source

Climate teleconnections synchronize Picea glauca masting and fire disturbance: Evidence for a fire‐related form of environmental prediction [PDF]

, 2019
1.Synchronous pulses of seed masting and natural disturbance have positive feedbacks on the reproduction of masting species in disturbance‐prone ecosystems. We test the hypotheses that disturbances and proximate causes of masting are correlated, and that
LaMontagne, JM, Maringer, J, Adrián Cardil, Davide Ascoli, Cardil, A, Motta, R., Vacchiano, G., Andrew Hacket‐Pain, Motta, R, Pearse, IS, Maringer, J., Cardil, A., Conedera, M., Hacket Pain, AJ, Giorgio Vacchiano, Ascoli, D, Ascoli, D., Hacket‐Pain, A., Pearse, I. S., Marco Conedera, Janet Maringer, Conedera, M, Jalene M. LaMontagne, Renzo Motta, Ian S. Pearse, Vacchiano, G, LaMontagne, J. M.   +26 more
core   +1 more source

Araucaria araucana and the Austral parakeet: pre-dispersal seed predation on a masting species El pehuén y la cachaña: depredación predispersión de una especie "masting"

Revista Chilena de Historia Natural, 2008
Pre-dispersal seed predation by Austral parakeets, Enicognathus ferrugineus, on pehuén, Araucaria araucana, was studied to assess the relationship between predation and seed production. We collected falling seeds in four araucaria forests of southwestern
JOHN D SHEPHERD, REBECCA S DITGEN, JAVIER SANGUINETTI   +2 more
doaj  

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Masting Dynamics data set

, 2011
This group compiled an extensive data base of time series for masting species with associated climatic data. Individual seed production in 59 populations of plants from 24 species spanning a large range of annual variablilty, from species exhibiting ...

core  

Efectos de la producción de semillas y la heterogeneidad vegetal sobre la supervivencia de semillas y el patrón espacio-temporal de establecimiento de plántulas en Araucaria araucana Araucaria araucana temporal and spatial seedling establishment patterns: masting, seed predation and understory vegetation effects

Revista Chilena de Historia Natural, 2009
El establecimiento de plántulas puede estar limitado por la producción de semillas y asociada a la producción intermitente y sincronizada de semillas (masting) y/o por granivoría, o por falta de micrositios aptos para la germinación y crecimiento de las ...
JAVIER SANGUINETTI, THOMAS KITZBERGER
doaj  

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source