Results 101 to 110 of about 2,109 (292)
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu +4 more
wiley +1 more source
Masting behaviour and dendrochronology of European beech (Fagus sylvatica L.) in southern Sweden
To identify weather controls of beech diameter growth and masting in southern Sweden, we analyze records of monthly weather, regional masting record, and tree-ring chronologies from five beech-dominated stands.
Drobyshev, Igor +6 more
core +2 more sources
Identifying the mechanisms that structure niche breadth and overlap between species is important for determining how species interact and assessing their functional role in an ecosystem.
Ryan B. Stephens +3 more
doaj +1 more source
Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang +17 more
wiley +1 more source
Mast cells and basophils [PDF]
Mast cells and basophils are effector cells in IgE-associated immune responses, such as those that contribute to asthma and other allergic diseases and to host resistance to parasites. Recent work shows that mast cells can also participate in innate immunity to bacterial infection and that the expression of such mast cell-dependent natural immunity can
openaire +2 more sources
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Se describe un episodio de fructificación en masa en una población de Peltogyne purpurea de la Península de Osa, Costa Rica. En febrero y marzo de 2000, la mayor parte de los árboles de esta especie tuvo una gran cosecha de frutos. En los años anteriores,
Oscar J Rocha +2 more
doaj
Climate oscillations affect weather on different temporal-spatial scales, which poses difficulty in understanding how they influence tree reproduction. Here Ascoli et al.
Davide Ascoli +7 more
doaj +1 more source
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou +8 more
wiley +1 more source
When bamboo flowers: ecological shifts and conservation challenges
Mass flowering of bamboo, a rare yet ecologically significant event, acts as a landscape-level catalyst with profound consequences for forest ecosystems and adjacent human societies.
Thavalathadathil Velayudhan Sajeev
doaj +1 more source

