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The Mast Cells

1989
Mast cells are normal inhabitants of the connective tissue of most organs. They are characterized by a content of numerous large, electron dense granules which are made up of a proteoglycan matrix showing a metachromatic staining pattern due to its content of strongly sulphated glycosaminoglycans (GAG). The mast cells also contain histamine and are the
L, Enerbäck, K, Norrby
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Identification of Mast Cells and Mast Cell Subpopulations

2008
Mast cells generate mediators of inflammation which are stored in granules and secreted on activation either by allergen crosslinking of membrane-bound IgE or through other stimuli. Most methods for mast cell identification rely on the histochemical detection of constituents of the secretory granules. Although staining for mast cells with histochemical
Buckley, Mark, Walls, Andrew F.
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Human mast cell proteases and mast cell heterogeneity

Current Opinion in Immunology, 1988
Mast cell neutral proteases are distinctive markers of the MC(T) and MC(TC) cells in humans. Measurements of tryptase levels in vivo serve as an overall indicator of mast cell activity. Further research is needed to evaluate the functional role of these proteases as well as each mast cell type in situations related to both health and disease.
J S, Miller, L B, Schwartz
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Mast cells and aging

Advances in Gerontology, 2017
Mast cells (MC) are present in the skin and mucous membranes, lymphoid organs, intestine wall and brain, where they are located close to the blood and lymphatic vessels and nerve terminals. As a source of a large number of biologically active substances, many of which are released quickly into the environment as a result of degranulation process, mast ...
N A, Kutukova   +3 more
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Mast cells and cancer

Giornale Italiano di Dermatologia e Venereologia, 2019
Mast cells (MCs) are a potent proangiogenic factor in tumors, they product several pro-angiogenic factors such as fibroblast growth factor 2 (FGF-2), vascular epithelial growth factor (VEGF), tryptase and chymase. Tryptase is a serine protease classified as α-tryptase and β-tryptase, both produced by MCs.
Giovanni, Paolino   +8 more
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Mast Cell Pleomorphism: Properties of Intestinal Mast Cells

1987
Consistent with their nearly ubiquitous distribution throughout the body, mast cells interact with a variety of cell types and react to numerous environmental stimuli. They can be activated by macrophage (1) and T cell factors (2), by complement fragments, as well as by IgE-allergen interactions.
M, Swieter   +4 more
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Mast

SIMULATION, 1983
The MAnufacturing System Design Tool (MAST) is a simula tion aid for designing a flexible manufacturing system (FMS) involving machine tools. MAST models can represent a variety of hardware components and process control algorithms. This software control lets the designer study the compatibility of FMS hardware and software.
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Mast cells in atherosclerosis

Thrombosis and Haemostasis, 2011
SummaryThe mast cell, a potent inflammatory cell type, is widely distributed over several tissues, but particularly prominent at the interface exposed to the environment to act in the first line of defense against pathogens. Upon activation mast cells release granules, which contain a large panel of mediators, including neutral proteases (e.g.
Bot, Ilze, Biessen, Erik A. L.
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Mast Cell Proteases

2007
Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by causing many of the symptoms associated with allergic reactions. In addition, recent research has put focus on MCs for displaying harmful effects during various autoimmune disorders.
Gunnar, Pejler   +3 more
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On the Heterogeneity of Mast Cells

Pharmacology, 2008
Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed.
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