Results 121 to 130 of about 81,928 (305)

Baseline Serum Tryptase: Sex‐ and Age‐Specific Reference Intervals in the Pediatric and Adult Population

Allergy, EarlyView.
Yannick Chantran, Hélène Novakowski, Amandine Vial‐Dupuy, Christine Bouz, Pol André Apoil, Simone Choi, Eric Fromentin, Julien Goret, Patricia Mathieu, Moïse Michel, Ariane Nemni, Edouard Sève, Céline Roda, Fanny Rancière, Joana Vitte, Isabelle Momas, Caroline Klingebiel, On the behalf of the GTBA of the SFA   +17 more
wiley   +1 more source

The Changing Epidemiology of Breakthrough Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients in the Era of Modified‐Release Posaconazole Prophylaxis

Transplant Infectious Disease, EarlyView.
This single‐center retrospective cohort study on 300 allogeneic hematopoietic stem cell transplant recipients from January 2017 to May 2020, in which posaconazole modified release was the most common primary antifungal prophylaxis, demonstrated a breakthrough invasive fungal disease (bIFD) rate of 9%, with associated significant all‐cause mortality at ...
Shio Yen Tio, Chin Fen Neoh, David Ritchie, Lynette Chee, David C. M. Kong, Leon J. Worth, Michelle K. Yong, Monica A. Slavin   +7 more
wiley   +1 more source

Preclinical human models and emerging therapeutics for advanced systemic mastocytosis

Haematologica, 2018
Mastocytosis is a term used to denote a group of rare diseases characterized by an abnormal accumulation of neoplastic mast cells in various tissues and organs.
Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent   +10 more
doaj   +1 more source

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms [PDF]

, 2015
Myeloproliferative neoplasms (MPN) are a diverse group of chronic hematological disorders that involve unregulated clonal proliferation of white blood cells.
Kapur, Reuben, Pandey, Ruchi
core   +1 more source

Granulocyte Transfusions in Pediatric Hemato‐Oncology: Neutrophil Response and CRP Kinetics

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Background Granulocyte transfusions (GTXs) are used in neutropenic pediatric hemato‐oncology patients with infections unresponsive to antimicrobial therapy, but their clinical benefit remains uncertain. Methods We retrospectively reviewed all pediatric patients who received GTXs between 2013 and 2023 at a tertiary medical center.
Aviv Sever, Ron Rabinowicz, Shlomit Barzilai‐Birenboim, Salvador Fisher, Ronit Goldman Levi, Assaf Yanir, Jerry Stein, Efraim Bilavsky, Joanne Yacobovich, Vered Yahalom   +9 more
wiley   +1 more source

Regulation of mast cell function and survival in health and disease [PDF]

, 2016
Mast cells are sentinels of danger but they are also the major effector cells in allergic disease causing the well-known allergic symptoms caused by their mediators such as histamine and prostaglandin D2 that are released upon activation. Mastocytosis is
Lyberg, Katarina
core   +1 more source

Challenges in Extrapolating Healthy Volunteer Pharmacokinetics to Oncology Populations: Advocating for a Holistic Perspective

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Phase I clinical pharmacology (CP) studies in healthy volunteers (HVs) are conducted to assess factors influencing drug pharmacokinetic (PK) properties and guide potential dose adjustments or restrictions for specific subpopulations within the target patient population.
Yan Ji, Romain Sechaud, Abhijit Chakraborty   +2 more
wiley   +1 more source

Allergen-specific immunotherapy of Hymenoptera venom allergy:also a matter of diagnosis [PDF]

, 2015
Stings of hymenoptera can induce IgE-mediated hypersensitivity reactions in venom-allergic patients, ranging from local up to severe systemic reactions and even fatal anaphylaxis.
Schiener, Maximilian, Graessel, Anke, Ollert, Markus, Schmidt-Weber, Carsten B, Blank, Simon   +4 more
core   +2 more sources

A Phase 2 study of CPX‐351 in combination with venetoclax in patients with newly diagnosed high‐risk acute myeloid leukemia

HemaSphere, Volume 9, Issue 10, October 2025.
Abstract Venetoclax has been combined with intensive chemotherapy regimens in the treatment of acute myeloid leukemia (AML). We aimed to investigate the safety and efficacy of venetoclax combined with full‐dose CPX‐351 (CPX + VEN) in newly diagnosed (ND) AML.
Wei‐Ying Jen, Jennifer Croden, Emmanuel Almanza‐Huante, Courtney DiNardo, Kelly Chien, Danielle Hammond, Wei Qiao, Yesid Alvarado, Lucia Masarova, Andres E. Quesada, Sherry Pierce, Alex Bataller, Guillermo Garcia‐Manero, Amin Alousi, Nicholas Short, Naval Daver, Farhad Ravandi, Hagop Kantarjian, Tapan M. Kadia   +18 more
wiley   +1 more source

The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype [PDF]

, 2003
T helper cell (Th1 and Th2) associated responses were examined following a primary infection with the gastrointestinal nematode Heligmosomoides polygyrus in five inbred strains of mice with different resistance phenotypes.
Behnke, Jerzy M., Ben-Smith, A.W., Lammas, D.A.   +2 more
core   +2 more sources