Results 71 to 80 of about 227,065 (305)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer:a matched pair analysis

, 2020
Background: Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes.
Nair, Sudhir, Hisham Mehanna, Sudhir Nair, Atanu Bhattacharjee, Singh, Arjun, Chaturvedi, Pankaj, Akshat Malik, Malik, Akshat, Komal Lamba, Rane, Swapnil, Swapnil Rane, Munita Bal, Lamba, Komal, Bhattacharjee, Atanu, Arjun Singh, Bal, Munita, Pankaj Chaturvedi, Mehanna, Hisham; id_orcid   +17 more
core   +1 more source

Multimodal Approach Combining Thulium Laser Vaporization, Bipolar Transurethral Resection of the Prostate, and Bipolar Plasma Vaporization versus Bipolar Transurethral Resection of the Prostate: A Matched-Pair Analysis. [PDF]

J Clin Med
Background/Objectives: The aim of our study is to compare the perioperative and functional outcomes of a multimodal approach combining thulium laser vaporization, bipolar TURP, and bipolar plasma vaporization (TLP) with bipolar TURP in a matched-pair ...
Coman RA, Coman RT, Popescu RI, Leucuta DC, Couți R, Coman I, Al Hajjar N.   +6 more
europepmc   +2 more sources

Is there a Role for the Appleby Procedure in 2020? Results from a Matched-Pair-Analysis [PDF]

Anticancer Research, 2019
Locally advanced pancreatic cancer (LAPC) of the pancreatic body involving the celiac axis requires specialized treatment, including a subtotal distal pancreatectomy (SDP) with resection of the celiac axis (Appleby procedure). This study aimed to examine the value of the Appleby procedure, in current individualized treatment approaches, and to define ...
Thomas, Malinka, Lea, Timmermann, Fritz, Klein, Dominik, Geisel, Johann, Pratschke, Marcus, Bahra   +5 more
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Differences in Nasal Shapes and the Degree of Changes Over a Decade or More: A Paired Analysis [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. This study investigated age-related differences in nasal morphometry and the degree of changes within an individual over at least a 10-year period by pairing previous and recent three-dimensional reconstructed computed tomography (CT) images.
Younghac Kim, Joo Hyun Park, Minhae Park, Eunkyu Lee, Sang Duk Hong, Yong Gi Jung, Gwanghui Ryu, Hyo Yeol Kim   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Incidence, Outcomes and Sex-Related Disparities in Pneumonia: A Matched-Pair Analysis with Data from Spanish Hospitals (2016–2019)

, 2021
(1) Background: the purpose of this study is to analyze the incidence and in-hospital mortality (IHM) of community-acquired pneumonia (CAP) needing hospital admission and hospital-acquired pneumonia (HAP) in Spain (2016–2019).
Napoleon Perez-Farinos, Lopez-de-Andres, Ana, Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Carabantes Alarcón, David, Rodrigo Jiménez-Garcia, Miguel Díez, Javier De, Jose M. de Miguel-Yanes, Hernández Barrera, Valentín, Javier de Miguel-Diez, Jiménez García, Rodrigo, de Miguel-Yanes, Jose M., López De Andrés, Ana Isabel, Carabantes-Alarcon, David, Wärnberg, Julia, Jiménez-García, Rodrigo, de Miguel-Diez, Javier, Miguel Yanes, José María De, Pérez Farinós, Napoleón, Perez-Farinos, Napoleon, Hernandez-Barrera, Valentin, David Carabantes-Alarcon, Julia Wärnberg   +22 more
core   +2 more sources