Results 101 to 110 of about 62,132,774 (264)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Estimating Matching Games with Transfers [PDF]

Economists wish to use data on matches to learn about the structural primitives that govern sorting. I show how to use equilibrium data on who matches with whom for semiparametric estimation of match production functions in many-to-many, two-sided ...
Jeremy T. Fox
core  

Tarefas de Delayed Matching-to-Sample no Formato Remoto com Pessoas com Atraso no Desenvolvimento: uma Replicação Sistemática

Psicologia
O presente estudo teve como objetivo verificar o efeito de diferentes tempos de atraso em tarefas de discriminação condicional de identidade e arbitrária, em participantes com deficiência intelectual e TEA, aplicadas remotamente, e avaliar se as ...
Isabela de Oliveira Teixeira, Lidia Maria Marson Postalli   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analyzing the role of social variables and programmed consequences in instruction-following / Análise do papel de variáveis sociais e de conseqüências programadas no seguimento de instruções

Psicologia: Reflexão e Crítica, 2004
Twelve children in the eight-to-nine year age range were exposed to a matching-to-sample procedure in an investigation dealing with the role of monitoring in instruction-following.
Niele Márcia Amaral de Albuquerque, Carla Cristina Paiva Paracampo, Luiz Carlos de Albuquerque   +2 more
doaj  

Effects of linguistic interference on the acquisition and transfer of conditional discriminations with first- and second-order matching-to-sample tasks

Acta Colombiana de Psicología
Studies on conditional discrimination (CD) in humans have pointed out that linguistic contact with the properties and criteria of the task is critical both for acquisition and transfer, especially in extra-relational and extra-dimensional tests.
Alejandro León, Carlos Zenteno, Isiris Guzman, Iván Felipe Medina-Arboleda   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A mismatch process in brief delayed matching-to-sample task: an fMRI study

, 2008
Our previous ERP studies have consistently demonstrated that a negativity N270 elicited by incongruent information in visual S1-S2 matching task represents a type of conflict process, which is distinct from that represented by the classic conflict task ...
Li, Shunwei, X. Zhang, Weng, Xuchu, Ma, Lin, Wang, Yuping, Wang, Luning, Zhang, Xi   +6 more
core  

An analysis of the effects of history of behavioral variation on rule-following behavior / Análise dos efeitos de histórias de variação comportamental sobre o seguimento de regras

Psicologia: Reflexão e Crítica, 2004
In a study concerning the sensitivity of instruction-following to signaled changes in contingencies, 14 children in the 8-to-9 age range were exposed to a matching-to-sample procedure.
José Guilherme Wady Santos, Carla Cristina Paiva Paracampo, Luiz Carlos de Albuquerque   +2 more
doaj