Results 51 to 60 of about 1,191,687 (316)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Matching mentors and recent immigrants: matching criteria in social mentoring programmes for newcomers

open access: yesInternational Journal of Evidence Based Coaching and Mentoring, 2023
To improve the social participation of newcomer immigrants, social mentoring programs for newcomers have gained in popularity. This paper attempts to bring some clarity to the practice of social mentoring for newcomers by focusing on an important step in
Peter De Cuyper, Michelle Crijns
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Design of Query System of Belt Conveyor Protection of Coal Preparation Plant Based on VB

open access: yesGong-kuang zidonghua, 2011
Taking belt conveyor protection system of Daping Coal Preparation Plant as background, the paper introduced design of a query system of belt conveyor protection of coal preparation plant based on VB.
KOU Jun-li, YIN Jun
doaj  

Matchings and matching extensions in graphs

open access: yesDiscrete Mathematics, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Matching Polytons [PDF]

open access: yesThe Electronic Journal of Combinatorics, 2019
Hladký, Hu, and Piguet [Tilings in graphons, preprint] introduced the notions of matching and fractional vertex covers in graphons. These are counterparts to the corresponding notions in finite graphs.  Combinatorial optimization studies the structure of the matching polytope and the fractional vertex cover polytope of a graph.
Martin Dolezal, Jan Hladký
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Matching organ donors and patients [PDF]

open access: yesAnali Ekonomskog fakulteta u Subotici, 2017
In the transplantation it is illegal to sell organs for ethical reasons. In this market, demand is greater than supply and it is necessary to make the optimal allocation of scarce resources.
Trifunović Dejan
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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