Results 71 to 80 of about 1,846,953 (347)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

On one-loop corrections to matching conditions of Lattice HQET including 1/m_b terms [PDF]

open access: yes, 2013
HQET is an effective theory for QCD with N_f light quarks and a massive valence quark if the mass of the latter is much bigger than Lambda_QCD. As any effective theory, HQET is predictive only when a set of parameters has been determined through a ...
Korcyl, Piotr
core   +2 more sources

Colour Matching Function Learning [PDF]

open access: yes, 2012
In this paper, we aim at learning the colour matching functions making use of hyperspectral and trichromatic imagery. The method presented here is quite general in nature, being data driven and devoid of constrained setups. Here, we adopt a probabilistic formulation so as to recover the colour matching functions directly from trichromatic and ...
Luis Romero-Ortega, Antonio Robles-Kelly
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Efficient Dynamic Dictionary Matching with DAWGs and AC-automata

open access: yes, 2019
The dictionary matching is a task to find all occurrences of patterns in a set $D$ (called a dictionary) on a text $T$. The Aho-Corasick-automaton (AC-automaton) is a data structure which enables us to solve the dictionary matching problem in $O(d\log ...
Hendrian, Diptarama   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Service function chain deployment algorithm based on optimal weighted graph matching

open access: yesTongxin xuebao, 2019
Service function chain can support flexible network service requirement by linking virtual network functions.Aiming at the problem of service function chain deployment in a resource-constrained network,an algorithm for service function chain deployment ...
Dan LI   +3 more
doaj   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

First-principles transport calculation method based on real-space finite-difference nonequilibrium Green's function scheme [PDF]

open access: yes, 2012
We demonstrate an efficient nonequilibrium Green's function transport calculation procedure based on the real-space finite-difference method. The direct inversion of matrices for obtaining the self-energy terms of electrodes is computationally demanding ...
F. García-Moliner   +7 more
core   +3 more sources

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