Results 51 to 60 of about 389,994 (266)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

CORRESPONDENCE MATCHING IN 3D MODELS FOR 3D HAND FITTING

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
Upper limb prosthetic is an area of medical research and development that aims to restore functionality and improve the quality of life of people affected by the loss of one or both upper limbs.
Maksym Tymkovych, Oleg Avrunin, Karina Selivanova, Alona Kolomiiets, Taras Bednarchyk, Saule Smailova   +5 more
doaj   +1 more source

Pattern Matching Fuzzy Models for Time series Forecasting with Application [PDF]

المجلة العراقية للعلوم الاحصائية, 2009
We study a new technique of forecasting time series , this is technique is pattern matching Fuzzy, which identify past relationships and its trends in historical data for forecasting future values .We connect Fuzzy Pattern Matching model with time ...
doaj   +1 more source

Text Matching Model Based on Dependency Relation and Neural Network [PDF]

Jisuanji gongcheng, 2019
In order to enhance the text semantic capture ability of text matching model and improve the semantic matching accuracy,a text matching model based on word embedding and dependency relation is proposed.It constructs the semantic representation of the ...
ZHEN Zhuo, CHEN Yuquan
doaj   +1 more source

Ideal Model-Matching

IFAC Proceedings Volumes, 1990
Abstract The linear continuous basic time-invariant control system consisting of a generator of a command variable, of an ideal model response and of the control process is fitted up by three controllers: one in the feedback and two in the feedforward.
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A new CNN deep learning model for computer-intelligent color matching

Nonlinear Engineering
To accurately color the clothing of textile enterprises, many scholars have proposed intelligent color-matching models. However, these intelligent color-matching models still have problems with incomplete color-matching functions and low color-matching ...
He Zhibin, Tan Yanmei, Li Sa
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Matching patients to clinical trials with large language models

Nature Communications
Patient recruitment is challenging for clinical trials. We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models.
Qiao Jin, Zifeng Wang, Charalampos S. Floudas, Fangyuan Chen, Changlin Gong, Dara Bracken-Clarke, Elisabetta Xue, Yifan Yang, Jimeng Sun, Zhiyong Lu   +9 more
doaj   +1 more source