Results 131 to 140 of about 10,152,062 (308)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Maximum Number of Dominating Induced Matchings
Journal of Graph Theory, 2014 AbstractA matching M of a graph G is a dominating induced matching (DIM) of G if every edge of G is either in M or adjacent with exactly one edge in M. We prove sharp upper bounds on the number of DIMs of a graph G and characterize all extremal graphs.
Lin, Min Chih +3 more
openaire +4 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Complexity of deciding the equality of matching numbers
Journal of Computer and System SciencesA matching is said to be disconnected if the saturated vertices induce a disconnected subgraph and induced if the saturated vertices induce a 1-regular graph. The disconnected and induced matching numbers are defined as the maximum cardinality of such matchings, respectively, and are known to be NP-hard to compute.
Guilherme C. M. Gomes +6 more
openaire +3 more sources
Design of adaptive matching true random number generator based on thermal noise
Dianzi Jishu Yingyong, 2018 After studying on the thermal noise model and the matching mechanism of sensitive amplifier, an adaptively matching True Random Number Generator(TRNG) design is proposed.
Li Zhen, Wang Pengjun, Cheng Xu, Li Gang
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
On propensity score matching with a diverging number of matches
BiometrikaAbstract This paper re-examines the work of Abadie & Imbens (2016) on propensity score matching for average treatment effect estimation. We explore the asymptotic behaviour of these estimators when the number of nearest neighbours, M, grows with the sample size.
He, Yihui, Han, Fang
openaire +3 more sources
We define the median stable matching for two-sided matching markets with side payments and prove constructively that it exists.
Michael Schwarz, M. Bumin Yenmez
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