Results 61 to 70 of about 1,538,393 (213)

Pure Exploration with Multiple Correct Answers [PDF]

, 2019
We determine the sample complexity of pure exploration bandit problems with multiple good answers. We derive a lower bound using a new game equilibrium argument.
Degenne, Rémy, Koolen, Wouter M.
core   +1 more source

Attentional enhancement in matching-to-sample: Facilitation in matching acquisition by sample-discrimination training [PDF]

Animal Learning & Behavior, 1989
In three experiments, we examined how matching-to-sample by pigeons is affected by discrimination versus nondifferential training between the matching stimuli. In Experiment 1A, pigeons responding differentially to the sample stimuli off-baseline acquired accurate matching performances more rapidly than did pigeons responding nondifferentially to those
Peter J. Urcuioli, Judy Callender
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Colour analysis of degraded parchment [PDF]

, 2013
Multispectral imaging was employed to collect data on the degradation of an 18th century parchment by a series of physical and chemical treatments. Each sample was photographed before and after treatment by a monochrome digital camera with 21 narrow-band
Giacometti, A, Gibson, A, Macdonald, LW, Terras, M, Weyrich, T   +4 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

How to Control for Many Covariates? Reliable Estimators Based on the Propensity Score [PDF]

We investigate the finite sample properties of a large number of estimators for the average treatment effect on the treated that are suitable when adjustment for observable covariates is required, like inverse probability weighting, kernel and other ...
Huber, Martin, Lechner, Michael, Wunsch, Conny   +2 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Numerical simulation and experimental validation of texture in extruded wires of a bcc metal [PDF]

, 2013
We present a comparison between a viscoplastic crystal plasticity finite element simulation of the extrusion process applied to a bcc polycrystal and the experimental evaluation of the preferred orientation (texture) in a tungsten wire by monochromatic ...
Bainpas, Nikolaos, Korsunsky, Alexander M., Reinhard, Christina, Xie, Mengyin   +3 more
core  

Infants’ representations of same and different in match- and non-match-to-sample [PDF]

Cognitive Psychology, 2016
Three experiments investigated the representations that underlie 14-month-old infants' and adults' success at match-to-sample (MTS) and non-match-to-sample (NMTS) tasks. In Experiment 1, 14-month-old infants were able to learn rules based on abstract representations of sameness and/or difference.
Hochmann, Jean-Remy, Mody, Shilpa, Carey, Susan   +2 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source