Results 61 to 70 of about 86,978 (136)

Characterization of the complete chloroplast genome of an endangered ornamental and medicinal plant Lilium pumilum

Mitochondrial DNA. Part B. Resources, 2020
Lilium pumilum DC. is a useful plant species not only for its showy flowers but also for its edible and medicinal values. Here we report on the complete chloroplast genome sequence of L. pumilum.
Jian Jin, Hao Liu, Can Zhong, Jing Xie, You Qin, Xuejuan Liang, Lin Chen, Ping Cai, Shuihan Zhang   +8 more
doaj   +1 more source

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

Animal Models and Experimental Medicine, EarlyView.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li, Yudong Wang, Liyong Liu, Mengmeng Gong, Jinlong Wang, Yuqing Cao, Zhixin Sun, Fanliang Meng, Qiuyan Wang, Hongji Wu, Fei Zhao, Yan Ma, Yibai Xiong   +12 more
wiley   +1 more source

Pro-cognitive efficacy of Prospekta in a rat model of age-associated cognitive impairment

BMC Neuroscience
Background Ageing is associated with lower levels of cognitive performance, and novel therapeutics are warranted to correct this defect. Aged rats represent a favourable model of human ageing.
Elena Kardash, Nataliya Petrova, Ksenia Ganina, Sergey Tarasov, Oleg Epstein   +4 more
doaj   +1 more source

Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway

Scientific Reports, 2020
Arachidonic acid (AA) signaling pathway is an important constituent of inflammatory processes. In our previous study, it was found that dihydro-stilbene gigantol relieved hepatic inflammation in mice with CCl4-induced acute liver injury. This study aimed
Yaru Xue, Qiangqiang Deng, Qingli Zhang, Zhenghua Ma, Binfan Chen, Xiaolu Yu, Huige Peng, Sheng Yao, Jia Liu, Yang Ye, Guoyu Pan   +10 more
doaj   +1 more source

Immunotropic Properties of Anaferon and Anaferon Pediatric

Антибиотики и Химиотерапия, 2020
Anaferon and pediatric anaferon based on release-active antibodies to interferon-γ (R-A antibodies to INF-γ) proved to be efficient in the treatment of many viral infections.
E. S. Zhavbert, Yu. L. Dugina, O. I. Epstein   +2 more
doaj  

ANTI-INFLAMMATORY AND ANTI-ALLERGIC FEATURES OF ANTIBODIES TO HISTAMINE IN RELEASE-ACTIVE FORM: REVIEW OF EXPERIMENTAL AND CLINICAL RESEARCHES

Детские инфекции (Москва), 2015
Preclinical and clinical studies of medical preparations (rengalin, ergoferon) containing release-active (P-A) antibodies to histamine confirmed their ability to provide anti-inflammatory and anti-allergic effect.
E. S. Zhavbert, Yu. L. Dugina, O. I. Epshtein   +2 more
doaj   +1 more source

Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review

Pharmaceutical Biology, 2020
Context Acetylshikonin, a naphthoquinone derivative, is mainly extracted from some species of the family Boraginaceae, such as Lithospermum erythrorhizon Sieb. et Zucc., Arnebia euchroma (Royle) Johnst., and Arnebia guttata Bunge. As a bioactive compound,
Zhiqin Zhang, Jie Bai, Yawen Zeng, Mengru Cai, Yu Yao, Huimin Wu, Longtai You, Xiaoxv Dong, Jian Ni   +8 more
doaj   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

BMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu, Baoqin Song, Zhihao Chen, Wenzhong Li, Wanjun Liang, Xiu Wang   +5 more
wiley   +1 more source

Controllable engineered probiotic microspheres for treating ulcerative colitis: A cascade enzyme‐catalyzed strategy to restore intestinal redox homeostasis

BMEMat, EarlyView.
A dual strategy integrating genetic engineering and physical encapsulation was proposed to enhance the cell viability and antioxidant properties of probiotics. The cascade antioxidant enzymes released from probiotic microspheres restore intestinal redox homeostasis by eliminating intestinal reactive oxygen species for ulcerative colitis treatment ...
Xiaolong Mao, Xiangwei Lv, Miaomiao Zhang, Jiayi Liu, Yun Chen, Yunna Li, Gaoyuan Liu, Fuming Yang, Ziqiang Han, Yunyun Wei   +9 more
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source