Results 131 to 140 of about 3,960,500 (346)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Medieval Women, Material Culture, and Power: Matilda Plantagenet and her Sisters [PDF]

, 2020
Jitske Jasperse
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Through the lens of color: Relationships between color properties and visual perception of wood (Acer.) figures

Materials & Design
The wood figure is a crucial wood trait that contributes to its versatile applications, drawing attention and inspiring imagination. This study aims to elucidate the impact of color attributes on the visual perception of wood figures.
Jiapei Qin, Chao Li, Weiting Wang, Yuxiang Yu, Danni Shen, Defu Bao   +5 more
doaj   +1 more source

Analysis of the 19th Century Historic Archaeological Material Culture Remains from the Browning Site in Smith County, Texas [PDF]

, 2011
The Browning site (41SM195A) is located on a 3800 m2 alluvial terrace that overlooks the Auburn Creek floodplain in eastern Smith County, Texas. This setting is near the headwaters of a stream system in the Harris Creek drainage; Harris Creek meets the ...
Perttula, Timothy K., Walters, Mark
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Reconstruction of the Technology for Manufacturing Slate Knives Based on the Results of Studying Materials from Sites of Ancient and Historical Eskimos

Поволжская археология
The article deals with reconstruction of the technology for making slate knives of the Eskimos of Chukotka and Russian America, obtained during archaeological excavations and ethnographic collections. To achieve this goal, a comprehensive methodology for
Skakun Natalia N. , Terekhina Vera V. , Heredia Jose, Agakhanova Vitaliya A.   +3 more
doaj   +1 more source

Affordances theory as an operational framework for interpretation of past material culture and practices. Praxiography of things, bodies, and motions [PDF]

, 2020
Maciej Talaga
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A quantitative workflow for modeling diversification in material culture. [PDF]

PLoS One, 2020
Gjesfjeld E, Silvestro D, Chang J, Koch B, Foster JG, Alfaro ME.   +5 more
europepmc   +1 more source